The buckling instability of aggregating red blood cells.
The buckling instability of aggregating red blood cells.
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DOI：
10.1038/s41598-017-07634-6
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发表时间：
2017-08-11
影响因子：
4.6
通讯作者：
Wagner C
中科院分区：
文献类型：
--
作者：
Flormann D;Aouane O;Kaestner L;Ruloff C;Misbah C;Podgorski T;Wagner C
血浆蛋白如纤维蛋白原诱导红细胞（RBC）聚集成红细胞叠连，红细胞叠连是血液显著的剪切稀化行为的原因，控制红细胞沉降率（ESR）--一种常见的血液学测试--并且参与许多生理相关的情况，如微循环中血液的结构化或病理情况下的凝块形成。共聚焦显微镜用于表征红细胞在红细胞红细胞红三种不同的配置，只有部分预测之前，即降落伞，男女和S形形状，并定量恢复的数值模拟。一个详细的实验和理论分析表明，两个细胞的集群的变形与相互作用能非线性增加。模型表明，在一个临界值的相互作用能的接触膜经历了屈曲不稳定从一个平面到变形的接触区的前向分叉。这些结果不仅与理解RBC聚集体的形态和稳定性有关，而且还与一类相互作用的软变形物体如囊泡、胶囊或组织中的细胞有关。
Plasma proteins such as fibrinogen induce the aggregation of red blood cells (RBC) into rouleaux, which are responsible for the pronounced shear thinning behavior of blood, control the erythrocyte sedimentation rate (ESR) – a common hematological test – and are involved in many situations of physiological relevance such as structuration of blood in the microcirculation or clot formation in pathological situations. Confocal microscopy is used to characterize the shape of RBCs within rouleaux at equilibrium as a function of macromolecular concentration, revealing the diversity of contact zone morphology. Three different configurations that have only been partly predicted before are identified, namely parachute, male-female and sigmoid shapes, and quantitatively recovered by numerical simulations. A detailed experimental and theoretical analysis of clusters of two cells shows that the deformation increases nonlinearly with the interaction energy. Models indicate a forward bifurcation in which the contacting membrane undergoes a buckling instability from a flat to a deformed contact zone at a critical value of the interaction energy. These results are not only relevant for the understanding of the morphology and stability of RBC aggregates, but also for a whole class of interacting soft deformable objects such as vesicles, capsules or cells in tissues.
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影响因子：
3.8
作者：
Jan, K M;Chien, S
通讯作者：
Chien, S
影响因子：
3.4
作者：
ADAMS, KH
通讯作者：
ADAMS, KH
影响因子：
9.9
作者：
BROOKS, DE
通讯作者：
BROOKS, DE
影响因子：
8.6
作者：
Kaoui, Badr;Biros, George;Misbah, Chaouqi
通讯作者：
Misbah, Chaouqi
DOI：
10.1002/jss.400010418
发表时间：
1973-01-01
期刊：
Journal of Supramolecular Structure
影响因子：
--
作者：
CHIEN S;JAN K-M
通讯作者：
JAN K-M