Occurrence, spatial and seasonal variation, and environmental risk of pharmaceutically active compounds in the Pearl River basin, South China
Occurrence, spatial and seasonal variation, and environmental risk of pharmaceutically active compounds in the Pearl River basin, South China
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华南珠江流域药物活性化合物的发生、时空变化及环境风险
DOI：
10.1007/s11783-023-1646-8
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发表时间：
2022-10
影响因子：
6.4
通讯作者：
Guang-Guo Ying
中科院分区：
文献类型：
--
作者：
Hao-Jun Lei;Kai-Sheng Yao;Bin Yang;Ling-Tian Xie;Guang-Guo Ying
对华南珠江流域北江、西江、茅洲河地表水体和沉积物中40种药物活性化合物(PhACs)的存在、去向和环境风险进行了全面调查。水杨酸和双氯芬酸（抗炎药）、吉非罗齐（一种脂质调节剂）、卡马西平（一种抗癫痫药）、地西泮（一种精神活性药物）和 2-甲基-4-氯苯氧乙酸（MCPA，一种农药）是研究地区最普遍的化合物。地表水和沉积物中检测到的 PhAC 平均浓度分别为 0.17 至 19.1 ng/L 和 0.10 至 10.4 ng/g。同时，北江、西江、茅洲河地表水体和沉积物中PhACs浓度存在较大差异。西江和北江PHACs年通量最大均超过11 000 kg/a，而茅洲河仅25.7 kg/a。此外，北江、西江、茅洲河PhACs估算排放量分别为0.28~4.22 kg/a、0.12~6.72 kg/a、6.66~91.0 kg/a，回算使用量范围为12.0~293 kg/a、6.79~944 kg/a、 368 至 17 459 公斤/年。此外，PhAC的排放量与珠江沿岸各城市的国内生产总值（GDP）存在密切关系。环境风险评估表明，地西泮和布洛芬在该地区具有中等风险。
The occurrence, fate, and environmental risk of 40 pharmaceutically active compounds (PhACs) from surface waters and sediments were comprehensively investigated in the Beijiang River, Xijiang River, and Maozhou River of the Pearl River basin, South China. Salicylic acid and diclofenac (antiinflammatory drugs), gemfibrozil (a lipid regulator), carbamazepine (an antiepileptic drug), diazepam (a psychoactive drug), and 2-methyl-4-chloro-phenoxyacetic acid (MCPA, a pesticide) were the most ubiquitous compounds in the studied region. The average concentrations of detected PhACs in surface waters and sediments ranged from 0.17 to 19.1 ng/L and 0.10 to 10.4 ng/g, respectively. Meanwhile, PhACs concentration in surface waters and sediments varied greatly among and within the Beijiang River, Xijiang River, and Maozhou River. The largest annual flux of PhACs of the Xijiang River and Beijiang River was more than 11 000 kg per annum, whereas only 25.7 kg/a in the Maozhou River. In addition, the estimated emissions of PhACs in the Beijiang River, Xijiang River, and Maozhou River ranged respectively from 0.28 to 4.22 kg/a, 0.12 to 6.72 kg/a, and 6.66 to 91.0 kg/a, and the back-estimated usage varied with a range from 12.0 to 293 kg/a, 6.79 to 944 kg/a, 368 to 17 459 kg/a. Moreover, the emissions of PhACs showed a close relationship with the gross domestic product (GDP) of each city along the Pearl River. The environmental risk assessment suggested that diazepam and ibuprofen had a moderate risk in this region.
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中国北京药物活性化合物的特征：发生模式、时空分布及其环境影响
影响因子：
13.6
作者：
Ma Ruixue;Wang Bin;Yin Lina;Zhang Yizhe;Deng Shubo;Huang Jun;Wang Yujue;Yu Gang
通讯作者：
Yu Gang
影响因子：
7.7
作者：
T. Thiebault;M. Boussafir;C. Milbeau
通讯作者：
T. Thiebault;M. Boussafir;C. Milbeau
影响因子：
8.8
作者：
Biel-Maeso, Miriam;Corada-Fernandez, Carmen;Lara-Martin, Pablo A.
通讯作者：
Lara-Martin, Pablo A.
影响因子：
11.4
作者：
Oggier, Daniela M.;Weisbrod, Christin I.;Fent, Karl
通讯作者：
Fent, Karl
DOI：
10.1016/j.scitotenv.2018.04.267
发表时间：
2018-09
期刊：
The Science of the total environment
影响因子：
--
作者：
Huiju Lin;Leilei Chen;Hai-pu Li;Zhoufei Luo;Jing Lu;Zhao-guang Yang
通讯作者：
Huiju Lin;Leilei Chen;Hai-pu Li;Zhoufei Luo;Jing Lu;Zhao-guang Yang