Repletion of vitamin D associated with deterioration of sleep quality among postmenopausal women.
Repletion of vitamin D associated with deterioration of sleep quality among postmenopausal women.
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在绝经后妇女中，维生素D与睡眠质量恶化有关。
DOI：
10.1016/j.ypmed.2016.09.035
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发表时间：
2016-12
影响因子：
5.1
通讯作者：
McTiernan, Anne
中科院分区：
文献类型：
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作者：
Mason, Caitlin;Tapsoba, Jean de Dieu;Duggan, Catherine;Wang, Ching-Yun;Korde, Larissa;McTiernan, Anne
健康相关生活质量 (HRQOL) 下降、抑郁症状和睡眠质量差是绝经后女性的重要健康问题，可能与维生素 D 水平较低有关。在华盛顿州西雅图招募了血清 25-羟基维生素 D [25(OH)D] 10-32 ng/m 的超重绝经后女性（2010-2012 年），并随机分配至 12 个月减肥 + 2000 IU 口服维生素 D3/天或减肥 + 每日安慰剂组。减肥计划包括低热量饮食和每周 225 分钟的中度至剧烈有氧运动。 HRQOL 的八个分量表通过 MOS 36 项简短健康调查进行评估。使用简短症状量表 18 评估抑郁症状，并使用匹兹堡睡眠质量指数 (PSQI) 评估睡眠质量。使用广义估计方程比较各组（意向治疗）HRQOL、抑郁症状和睡眠质量的平均 12 个月变化。与安慰剂相比，接受维生素 D 的女性在抑郁症状 (p=0.78)、HRQOL 分量表（全部 p>0.05）或整体睡眠质量 (p=0.21) 方面没有出现任何显着变化。然而，血清 25(OH)D 变化幅度较大与服用药物入睡的需求增加 (ptrend=0.01) 和总体睡眠质量较差 (ptrend<0.01) 相关。与尽管补充维生素 D 仍低于 32 ng/mL 的女性相比，补充维生素 D（≥32 ng/mL）的女性的总 PSQI 睡眠质量评分也有所恶化，即使在调整相关协变量后也是如此（未补充：-5.7% 与补充：+6.2%，p<0.01）。对于正在减肥且循环维生素 D 水平较低的绝经后女性，每天补充 2000 IU 的维生素 D 可能会导致整体睡眠质量变差。
Reduced health-related quality of life (HRQOL), depressive symptoms and poor sleep quality are important health issues among postmenopausal women and may be associated with low vitamin D status. Overweight postmenopausal women, with serum 25-hydroxyvitamin D [25(OH)D] 10–32 ng/m, were recruited in Seattle, WA (2010–2012) and randomly assigned to 12 months of weight loss + 2000 IU oral vitamin D3/day or weight loss + daily placebo. The weight-loss program included a reduced-calorie diet and 225 min/week of moderate-to-vigorous aerobic activity. Eight subscales of HRQOL were assessed by the MOS 36-Item Short-Form Health Survey. Depressive symptoms were assessed using the Brief Symptom Inventory-18, and sleep quality was assessed using the Pittsburg Sleep Quality Index (PSQI). Mean 12-month changes in HRQOL, depressive symptoms and sleep quality were compared between groups (intent-to-treat) using generalized estimating equations. Compared to placebo, women receiving vitamin D did not experience any significant change in depressive symptoms (p=0.78), HRQOL subscales (all p>0.05), or overall sleep quality (p=0.21). However, a greater magnitude of change in serum 25(OH)D was associated with an increased need to take medications to sleep (ptrend=0.01) and overall worse sleep quality (ptrend<0.01). Women who became vitamin D replete (≥32 ng/mL) also showed a deterioration in total PSQI sleep quality score compared to women who remained <32 ng/mL despite supplementation, even after adjusting for relevant covariates (Non-Replete: −5.7% vs. Replete: +6.2%, p<0.01). Vitamin D supplementation of 2000 IU/d may result in overall worse sleep quality for postmenopausal women with low circulating vitamin D undergoing weight loss.
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DOI：
10.1186/1479-5868-8-118
发表时间：
2011-10-25
期刊：
The international journal of behavioral nutrition and physical activity
影响因子：
--
作者：
Imayama I;Alfano CM;Kong A;Foster-Schubert KE;Bain CE;Xiao L;Duggan C;Wang CY;Campbell KL;Blackburn GL;McTiernan A
通讯作者：
McTiernan A
影响因子：
4.7
作者：
Gominak, S. C.;Stumpf, W. E.
通讯作者：
Stumpf, W. E.
影响因子：
5.6
作者：
Bertisch, Suzanne M.;Sillau, Stefan;Redline, Susan
通讯作者：
Redline, Susan
影响因子：
4.4
作者：
Schreuder, Ferdinand;Bernsen, Roos M. D.;van der Wouden, Johannes C.
通讯作者：
van der Wouden, Johannes C.
影响因子：
5
作者：
Houston, Denise K.;Tooze, Janet A.;Kritchevsky, Stephen B.
通讯作者：
Kritchevsky, Stephen B.