Nanostructured guidance for peripheral nerve injuries: a review with a perspective in the oral and maxillofacial area.
Nanostructured guidance for peripheral nerve injuries: a review with a perspective in the oral and maxillofacial area.
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DOI：
10.3390/ijms15023088
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发表时间：
2014-02-20
影响因子：
5.6
通讯作者：
Zavan B
中科院分区：
文献类型：
--
作者：
Sivolella S;Brunello G;Ferrarese N;Della Puppa A;D'Avella D;Bressan E;Zavan B
周围神经损伤可能是各种外科手术的结果，包括口腔和颌面外科手术。在神经移植的情况下，金标准治疗是两个神经残端的端对端重新连接。当它不能执行时，实际的策略包括在两个残端之间放置神经移植物。利用纳米结构支架引导神经再生是一种很有前途的促进轴突再生的策略。由排列的纳米纤维组成的生物可降解电纺导管是一类用于改善神经突延伸和轴突生长的新型装置。自组装肽纳米纤维支架（SAPNSs）在中枢神经系统损伤的动物模型中表现出有希望的结果，最近，外周神经损伤。本文综述了静电纺丝和自组装纳米纤维支架在周围神经再生中的体内外应用，以及其在周围神经损伤治疗中的应用。该综述集中于直径小于约250 nm的纳米纤维支架。天然生物活性因子与可再吸收的合成或天然材料的纳米级缀合可能代表了为引导神经再生提供生物学和机械线索的最佳折衷。受损的周围神经，如三叉神经和面部神经，可能会受益于这些治疗。
Injury to peripheral nerves can occur as a result of various surgical procedures, including oral and maxillofacial surgery. In the case of nerve transaction, the gold standard treatment is the end-to-end reconnection of the two nerve stumps. When it cannot be performed, the actual strategies consist of the positioning of a nerve graft between the two stumps. Guided nerve regeneration using nano-structured scaffolds is a promising strategy to promote axon regeneration. Biodegradable electrospun conduits composed of aligned nanofibers is a new class of devices used to improve neurite extension and axon outgrowth. Self assembled peptide nanofibrous scaffolds (SAPNSs) demonstrated promising results in animal models for central nervous system injuries, and, more recently, for peripheral nerve injury. Aims of this work are (1) to review electrospun and self-assembled nanofibrous scaffolds use in vitro and in vivo for peripheral nerve regeneration; and (2) its application in peripheral nerve injuries treatment. The review focused on nanofibrous scaffolds with a diameter of less than approximately 250 nm. The conjugation in a nano scale of a natural bioactive factor with a resorbable synthetic or natural material may represent the best compromise providing both biological and mechanical cues for guided nerve regeneration. Injured peripheral nerves, such as trigeminal and facial, may benefit from these treatments.
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2.1
作者：
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DOI：
10.1073/pnas.97.12.6728
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