Contralateral projections of the rat anterior olfactory nucleus.
Contralateral projections of the rat anterior olfactory nucleus.
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DOI：
10.1002/cne.21900
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发表时间：
2009-01-01
影响因子：
2.5
通讯作者：
Eudy, Jennifer D.
中科院分区：
文献类型：
--
作者：
Illig, Kurt R.;Eudy, Jennifer D.
前嗅核（AON）是一个中枢嗅觉皮质结构，与嗅球（OB）和梨状皮质有密切的相互联系。虽然已经确定，通过与同侧和对侧OB、AON和梨状皮质的广泛连接，AON是嗅觉系统中双侧投射的主要来源，但很少有研究详细检查这种电路。在本研究中，我们在AON的特定亚区注射少量顺行示踪剂Phaseolus vulgaris白细胞凝集素（PHA-L）和逆行示踪剂氟金，以探索左右AON之间相互连接的地形。注射后对侧AON各部位均可见标记纤维。然而，详细的定量分析显示，AON的不同区域具有不同的半球间神经支配模式；对侧纤维主要集中在背侧和外侧AON亚区，而内侧和腹侧区域受到相对较轻的投射。这些结果显示了AON的半球间回路的重要特征，并提示AON的子区域在嗅觉信息处理中具有不同的功能作用。
The anterior olfactory nucleus (AON) is a central olfactory cortical structure that has heavy reciprocal connections with both the olfactory bulb (OB) and piriform cortex. While it has been firmly established that the AON is a primary source of bilateral projections in the olfactory system through extensive connections with both the ipsilateral and contralateral OB, AON and piriform cortex, few studies have examined this circuitry in detail. In the present study, we used small injections of the anterograde tracer Phaseolus vulgaris Leucoagglutinin (PHA-L) and the retrograde tracer Fluorogold in specific subregions of the AON to explore the topography of the interconnections between the left and right AONs. Labeled fibers were found in the contralateral AON following injections in all areas. However, detailed quantitative analyses revealed that different regions of the AON have distinct patterns of interhemispheric innervation; contralateral fibers were most heavily targeted to dorsal and lateral AON subregions, while the medial and ventral areas received relatively light projections. These results demonstrate important features of the interhemispheric circuitry of the AON, and suggest separate functional roles for subregions of the AON in olfactory information processing.
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影响因子：
2.5
作者：
HABERLY, LB;PRICE, JL
通讯作者：
PRICE, JL
影响因子：
2.5
作者：
Illig, KR
通讯作者：
Illig, KR
影响因子：
2.5
作者：
LUSKIN, MB;PRICE, JL
通讯作者：
PRICE, JL
影响因子：
2.5
作者：
SCHOENFELD, TA;MACRIDES, F
通讯作者：
MACRIDES, F
影响因子：
2.5
作者：
LUSKIN, MB;PRICE, JL
通讯作者：
PRICE, JL