Assessment of pre- and postnatal exposure to polychlorinated biphenyls: lessons from the Inuit Cohort Study.
Assessment of pre- and postnatal exposure to polychlorinated biphenyls: lessons from the Inuit Cohort Study.
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DOI：
10.1289/ehp.6054
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发表时间：
2003-07
影响因子：
10.4
通讯作者：
Inuit Cohort Study
中科院分区：
文献类型：
--
作者：
Ayotte P;Muckle G;Jacobson JL;Jacobson SW;Dewailly E;Inuit Cohort Study
多氯联苯 (PCB) 是食物链污染物，已被证明会对人类的发育产生不利影响。在一项旨在调查魁北克北部（加拿大努纳维克）因纽特人因环境 PCB 暴露引起的神经发育缺陷的流行病学研究过程中，我们比较了产前暴露的三种生物标志物和模型，以预测产后 6 个月的 PCB 血浆浓度。通过高分辨率气相色谱法和电子捕获检测技术，测量了从母体血浆、脐带血浆、母乳（产后约 1 个月收集）和 6 个月大婴儿血浆样本中提取的脂质中 14 种 PCB 同系物的浓度。在所有生物样品中观察到类似的同源物特征，并且 PCB-153（最丰富和持久的 PCB 同源物）与所有生物介质中其他经常检测到的 PCB 同源物密切相关。当以脂质为基础表达时，该同源物的母体血浆、脐带血浆和乳汁浓度具有很强的相关性，表明任何这些生物介质中的 PCB 浓度都是产前 PCB 暴露的良好指标。包括母亲 PCB-153 血浆脂质浓度、母乳喂养持续时间和两个皮褶厚度总和（婴儿身体脂肪量指数）在内的多变量模型解释了产后 6 个月时 PCB-153 血浆浓度差异的 72%（p < 0.001）。相比之下，根据母乳喂养时间乘以血脂中 PCB 浓度的乘积（在多项研究中用作产后 PCB 暴露指标），只能解释 36% 的婴儿血浆浓度。
Polychlorinated biphenyls (PCBs) are food-chain contaminants that have been shown to induce adverse developmental effects in humans. In the course of an epidemiologic study established to investigate neurodevelopmental deficits induced by environmental PCB exposure in the Inuit population of northern Québec (Nunavik, Canada), we compared three biomarkers of prenatal exposure and models to predict PCB plasma concentration at 6 months postpartum. Concentrations of 14 PCB congeners were measured by high-resolution gas chromatography with electron capture detection in lipids extracted from maternal plasma, cord plasma, breast milk (collected at approximately 1 month postpartum), and 6-month-old infant plasma samples. Similar congener profiles were observed in all biologic samples, and PCB-153, the most abundant and persistent PCB congener, was strongly correlated with other frequently detected PCB congeners in all biologic media. When expressed on a lipid basis, maternal plasma, cord plasma, and milk concentrations of this congener were strongly intercorrelated, indicating that PCB concentration in any of these biologic media is a good indicator of prenatal exposure to PCBs. A multivariate model that included maternal PCB-153 plasma lipid concentration, breast-feeding duration, and the sum of two skin-fold thicknesses (an index of infant body fat mass) explained 72% of PCB-153 plasma concentration variance at 6 months postpartum (p < 0.001). By contrast, based on the product of breast-feeding duration times the concentration of PCBs in plasma lipids, which was used as an index of postnatal PCB exposure in several studies, only 36% of infant plasma concentration was explained.
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影响因子：
4
作者：
JACOBSON, JL;JACOBSON, SW;BILLINGS, RL
通讯作者：
BILLINGS, RL
影响因子：
2.5
作者：
Huisman, M;KoopmanEsseboom, C;Touwen, BCL
通讯作者：
Touwen, BCL
影响因子：
2.5
作者：
HUISMAN, M;KOOPMANESSEBOOM, C;BOERSMA, ER
通讯作者：
BOERSMA, ER
影响因子：
4.6
作者：
JACOBSON, SW;FEIN, GG;DOWLER, JK
通讯作者：
DOWLER, JK
DOI：
10.1007/s002449900360
发表时间：
1998-07-01
影响因子：
4
作者：
Lanting, CI;Fidler, V;Boersma, ER
通讯作者：
Boersma, ER