The 5-HT7 receptor is involved in allocentric spatial memory information processing.
The 5-HT7 receptor is involved in allocentric spatial memory information processing.
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DOI：
10.1016/j.bbr.2009.03.011
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发表时间：
2009-08-24
影响因子：
2.7
通讯作者：
Hedlund, Peter B.
中科院分区：
文献类型：
--
作者：
Sarkisyan, Gor;Hedlund, Peter B.
海马体与空间记忆有关。它产生新神经元的能力被认为在记忆形成中发挥作用。海马血清素 (5-HT) 神经传递也被认为是记忆处理的贡献者。研究表明，5-HT7 受体以相对较高的丰度存在于海马体中。因此，本研究的目的是利用 5-HT7 受体缺陷型小鼠 (5-HT7-/-) 来研究 5-HT7 受体在空间记忆中的可能作用。使用新位置/新物体测试证明了 5-HT7-/- 小鼠的海马相关空间记忆缺陷。在用选择性 5-HT7 受体拮抗剂 SB-269970 治疗的 C57BL/6J 小鼠中观察到新位置探索的类似减少。这些发现促使使用 Barnes 迷宫进行扩展分析，证明 5-HT7-/- 小鼠在适应空间排列变化方面的效率低于 5-HT7+/+ 小鼠。 5-HT7-/-小鼠在解决空间任务所需的记忆编译方面存在特定损伤，导致异中心空间记忆受损，而在小鼠被迫从纹状体依赖性自我中心记忆切换回海马依赖性异中心记忆后，自我中心空间记忆保持完整。为了进一步研究这些行为的生理基础，我们使用 BrdU 免疫组织化学比较了 5-HT7+/+ 和 5-HT7-/- 小鼠的海马神经发生。两种基因型的齿状回细胞增殖率相同。根据当前数据，我们得出结论，5-HT7-/- 小鼠通过记住一系列简单的动作来成功定位静态环境中的隐藏目标。
The hippocampus has been implicated in aspects of spatial memory. Its ability to generate new neurons has been suggested to play a role in memory formation. Hippocampal serotonin (5-HT) neurotransmission has also been proposed as a contributor to memory processing. Studies have shown that the 5-HT7 receptor is present in the hippocampus in relatively high abundance. Thus the aim of the present study was to investigate the possible role of the 5-HT7 receptor in spatial memory using 5-HT7 receptor-deficient mice (5-HT7-/-). A hippocampus-associated spatial memory deficit in 5-HT7-/- mice was demonstrated using a novel location/novel object test. A similar reduction in novel location exploration was observed in C57BL/6J mice treated with the selective 5-HT7 receptor antagonist SB-269970. These findings prompted an extended analysis using the Barnes maze demonstrating that 5-HT7-/- mice were less efficient in accommodating to changes in spatial arrangement than 5-HT7+/+ mice. 5-HT7-/- mice had specific impairments in memory compilation required for resolving spatial tasks, which resulted in impaired allocentric spatial memory whereas egocentric spatial memory remained intact after the mice were forced to switch back from striatum-dependent egocentric to hippocampus-dependent allocentric memory. To further investigate the physiological bases underlining these behaviors we compared hippocampal neurogenesis in 5-HT7+/+ and 5-HT7-/- mice employing BrdU immunohistochemistry. The rate of cell proliferation in the dentate gyrus was identical in the two genotypes. From the current data we conclude that the 5-HT7-/- mice performed by remembering a simple sequence of actions that resulted in successfully locating a hidden target in a static environment.
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DOI：
10.1523/jneurosci.2192-08.2008
发表时间：
2008-10-01
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Berke JD
通讯作者：
Berke JD
影响因子：
2.7
作者：
Gasbarri, Antonella;Cifariello, Agata;Meneses, Alfredo
通讯作者：
Meneses, Alfredo
影响因子：
1.9
作者：
Goodrich-Hunsaker, Naomi J.;Hunsaker, Michael R.;Kesner, Raymond P.
通讯作者：
Kesner, Raymond P.
DOI：
10.1016/s0163-1047(88)90338-x
发表时间：
1988-05-01
期刊：
BEHAVIORAL AND NEURAL BIOLOGY
影响因子：
--
作者：
COOK, D;KESNER, RP
通讯作者：
KESNER, RP
DOI：
10.1073/pnas.91.23.11217
发表时间：
1994-11-08
影响因子：
11.1
作者：
BARNEA, A;NOTTEBOHM, F
通讯作者：
NOTTEBOHM, F