Genetic Modification of a Hox Locus Drives Mimetic Color Pattern Variation in a Highly Polymorphic Bumble Bee.
Genetic Modification of a Hox Locus Drives Mimetic Color Pattern Variation in a Highly Polymorphic Bumble Bee.
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Hox基因座的遗传修饰驱动高度多态性熊蜂的模仿颜色模式变异。
DOI：
10.1093/molbev/msad261
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发表时间：
2023-12-01
影响因子：
10.7
通讯作者：
Tian, Li
中科院分区：
文献类型：
--
作者：
Yang, Wanhu;Cui, Jixiang;Chen, Yuxin;Wang, Chao;Yin, Yuanzhi;Zhang, Wei;Liu, Shanlin;Sun, Cheng;Li, Hu;Duan, Yuange;Song, Fan;Cai, Wanzhi;Hines, Heather M.;Tian, Li
缪勒拟态为探索适应性表型趋异和趋同的机制提供了理想的自然复制，但拟态变异的遗传机制在很大程度上仍然未知。本研究探讨了一种高度多态性熊蜂（熊蜂属，蜜蜂科）的模仿颜色图案变异的遗传基础。在南亚，这个物种和多个comimetic物种收敛到当地的穆勒拟态模式，将腹部刚毛的颜色从橙子到黑色。橙子和黑色表型之间的遗传杂交表明，颜色二型性是由一个单一的孟德尔基因座控制，与橙子等位基因是显性黑色。全基因组关联表明，在2个腹部决定命运的Hox基因，abd-A和abd-B之间的基因间区域的位点与颜色变化相关。因此，这个基因座是在相同的基因间区域，但不是相同的确切的基因座，发现驱动红色黑色中腹部的变化，在一个遥远的相关熊蜂物种，熊蜂melanopygus。基因表达分析和RNA干扰表明，abd-A和abd-B之间的基因间长的非编码RNA的差异表达，在发病刚毛颜色分化可能会驱动橙子黑色的变化，造成同源异型转变后期的发展。分析这个相同的颜色基因座在comimetic物种揭示没有序列关联相同的颜色偏移，这表明模仿收敛是通过不同的遗传途径。我们的研究建立了Hox区域作为熊蜂颜色模式进化的基因组热点，并展示了多效性发育位点如何在自然界中驱动适应性辐射。
Müllerian mimicry provides natural replicates ideal for exploring mechanisms underlying adaptive phenotypic divergence and convergence, yet the genetic mechanisms underlying mimetic variation remain largely unknown. The current study investigates the genetic basis of mimetic color pattern variation in a highly polymorphic bumble bee, Bombus breviceps (Hymenoptera, Apidae). In South Asia, this species and multiple comimetic species converge onto local Müllerian mimicry patterns by shifting the abdominal setal color from orange to black. Genetic crossing between the orange and black phenotypes suggested the color dimorphism being controlled by a single Mendelian locus, with the orange allele being dominant over black. Genome-wide association suggests that a locus at the intergenic region between 2 abdominal fate-determining Hox genes, abd-A and Abd-B, is associated with the color change. This locus is therefore in the same intergenic region but not the same exact locus as found to drive red black midabdominal variation in a distantly related bumble bee species, Bombus melanopygus. Gene expression analysis and RNA interferences suggest that differential expression of an intergenic long noncoding RNA between abd-A and Abd-B at the onset setal color differentiation may drive the orange black color variation by causing a homeotic shift late in development. Analysis of this same color locus in comimetic species reveals no sequence association with the same color shift, suggesting that mimetic convergence is achieved through distinct genetic routes. Our study establishes Hox regions as genomic hotspots for color pattern evolution in bumble bees and demonstrates how pleiotropic developmental loci can drive adaptive radiations in nature.
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影响因子：
14.9
作者：
Hui JH;Marco A;Hunt S;Melling J;Griffiths-Jones S;Ronshaugen M
通讯作者：
Ronshaugen M
影响因子：
9.8
作者：
Joron M;Papa R;Beltrán M;Chamberlain N;Mavárez J;Baxter S;Abanto M;Bermingham E;Humphray SJ;Rogers J;Beasley H;Barlow K;ffrench-Constant RH;Mallet J;McMillan WO;Jiggins CD
通讯作者：
Jiggins CD
影响因子：
2.4
作者：
Huang, Jiaxing;Wu, Jie;Williams, Paul H.
通讯作者：
Williams, Paul H.
影响因子：
64.5
作者：
Jeong, Sangyun;Rokas, Antonis;Carroll, Sean B.
通讯作者：
Carroll, Sean B.
影响因子：
11.4
作者：
CELNIKER, SE;SHARMA, S;LEWIS, EB
通讯作者：
LEWIS, EB