When does age-related cognitive decline begin?
When does age-related cognitive decline begin?
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DOI：
10.1016/j.neurobiolaging.2008.09.023
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发表时间：
2009-04
影响因子：
4.2
通讯作者：
Salthouse, Timothy A.
中科院分区：
文献类型：
--
作者：
Salthouse, Timothy A.
横断面比较一致地显示，年龄增长与认知表现水平下降有关，即使在18岁至60岁的范围内也是如此。然而，由于纵向和横断面分析中发现的年龄趋势差异，年轻人和中年人认知功能横断面比较的有效性受到质疑。当前项目的结果表明，造成这种差异的一个主要因素是，在纵向比较中，与年龄相关的下降被与先前测试经验相关的大量积极影响所掩盖。本项目中三种估计复试影响的方法的结果，以及比较在恒定环境中饲养的非人类动物的研究结果，以及检查不受复试影响的神经生物学变量的研究结果，都集中在一个结论上，即与年龄相关的认知能力下降的某些方面在健康的受过教育的成年人中开始于20多岁和30多岁。
Cross-sectional comparisons have consistently revealed that increased age is associated with lower levels of cognitive performance, even in the range from 18 to 60 years of age. However, the validity of cross-sectional comparisons of cognitive functioning in young and middle-aged adults has been questioned because of the discrepant age trends found in longitudinal and cross-sectional analyses. The results of the current project suggest that a major factor contributing to the discrepancy is the masking of age-related declines in longitudinal comparisons by large positive effects associated with prior test experience. Results from three methods of estimating retest effects in this project, together with results from studies comparing non-human animals raised in constant environments and from studies examining neurobiological variables not susceptible to retest effects, converge on a conclusion that some aspects of age-related cognitive decline begin in healthy educated adults when they are in their 20s and 30s.
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影响因子：
3
作者：
Salthouse, TA
通讯作者：
Salthouse, TA
影响因子：
4
作者：
Salthouse, TA
通讯作者：
Salthouse, TA
影响因子：
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作者：
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通讯作者：
Fox, NC
影响因子：
2.7
作者：
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通讯作者：
Killiany, RJ
影响因子：
2.7
作者：
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通讯作者：
Savonenko, AV