Association of body mass index with chromosome damage levels and lung cancer risk among males.
Association of body mass index with chromosome damage levels and lung cancer risk among males.
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DOI：
10.1038/srep09458
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发表时间：
2015-03-30
影响因子：
4.6
通讯作者：
Guo H
中科院分区：
文献类型：
--
作者：
Li X;Bai Y;Wang S;Nyamathira SM;Zhang X;Zhang W;Wang T;Deng Q;He M;Zhang X;Wu T;Guo H
流行病学研究表明，身体质量指数（BMI）与癌症风险之间存在病因学联系，但支持这些观察结果的证据有限。本研究旨在探讨BMI与染色体损伤水平和肺癌风险的潜在关联。首先，我们从一家焦炉厂招募了1333名男性工人，检查他们的染色体损伤水平；然后，对12052名男性进行队列研究，以调查BMI与肺癌发病率的关系。我们进一步开展了基于队列研究的BMI和男性肺癌风险的荟萃分析。我们发现体重超重的男性工人（BMI≥25 kg/m2）的MN频率低于体重正常的男性（BMI: 18.5-24.9）。我们的队列研究表明，BMI≥25的男性发生肺癌的相对风险（RR）比正常体重男性低35%。进一步的荟萃分析显示，与正常体重的男性相比，BMI≥25的男性在东亚和其他人群中患肺癌的风险都降低了。这些结果表明，与体重正常的男性相比，体重超标的男性染色体损伤水平显著降低，患肺癌的风险也较低。然而，需要进一步的生物学研究来证实这些关联。
Epidemiological studies have shown an etiological link between body mass index (BMI) and cancer risk, but evidence supporting these observations is limited. This study aimed to investigate potential associations of BMI with chromosome damage levels and lung cancer risk. First, we recruited 1333 male workers from a coke-oven plant to examine their chromosome damage levels; and then, a cohort study of 12 052 males was used to investigate the association of BMI with lung cancer incidence. We further carried out a meta-analysis for BMI and male lung cancer risk based on cohort studies. We found that men workers with excess body weight (BMI ≥ 25 kg/m2) had lower levels of MN frequencies than men with normal-weight (BMI: 18.5–24.9). Our cohort study indicated that, the relative risk (RR) for men with BMI ≥ 25 to develop lung cancer was 35% lower than RR for normal-weight men. Further meta-analysis showed that, compared to normal-weight men, men with BMI ≥ 25 had decreased risk of lung cancer among both the East-Asians and others populations. These results indicate that men with excess body weight had significant decreased chromosome damage levels and lower risk of lung cancer than those with normal-weight. However, further biological researches were needed to validate these associations.
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