Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations.
Multiple OPR genes influence personality traits in substance dependent and healthy subjects in two American populations.
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DOI：
10.1002/ajmg.b.30701
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发表时间：
2008-10-05
期刊：
影响因子：
--
通讯作者：
Gelernter J
中科院分区：
文献类型：
--
作者：
Luo X;Zuo L;Kranzler H;Zhang H;Wang S;Gelernter J
性格特征是最复杂的数量特征之一。某些人格特征与物质依赖（SD）有关；遗传因素可能对两者都有影响。阿片受体（OPR）基因与SD之间的关联已有报道。本研究在病例对照样本中调查了OPR基因与人格特征之间的关系。我们评估了556名受试者的五因素人格模型维度：250名SD患者[181名欧洲裔美国人（EAs）和69名非洲裔美国人（AAs）]和306名健康受试者(266名欧洲裔美国人（EAs）和40名非洲裔美国人（AAs）]。在这些受试者中，我们对20个OPRM1标记、8个OPRD1标记和7个OPRK1标记以及38个非连锁的祖先信息标记进行了基因分型。使用MANCOVA分析了OPR基因与人格特质的关系，控制了基因-基因相互作用效应和潜在混杂因素。用Roy-Bargmann Stepdown ANCOVA对关联进行分解。人格性状与三个OPR基因的单倍型、双倍型、等位基因和基因型均存在主效应或交互效应（MANCOVA结果为0.002<p<0.046； ANCOVA结果为0.0004<p<0.049）。保守校正后，OPRM1的双倍型TTAGGA/TTCAGA对外向性有主要影响（p=0.008）， OPRM1^TTCAGA/TTCAGA和OPRD1^CAC/TAC对开放性有交互影响（p=0.010）。目前的研究表明，编码mu-， delta-和kappa-阿片受体的基因可能有助于人格特征的变化。此外，三个OPR基因对人格特征有显著的交互作用。这项工作提供了额外的证据，人格特征和障碍有部分重叠的遗传基础。
Personality traits are among the most complex quantitative traits. Certain personality traits are associated with substance dependence (SD); genetic factors may influence both. Associations between opioid receptor (OPR) genes and SD have been reported. This study investigated the relationship between OPR genes and personality traits in a case-control sample. We assessed dimensions of the five-factor model of personality in 556 subjects: 250 with SD [181 European-Americans (EAs) and 69 African-Americans (AAs)] and 306 healthy subjects (266 EAs and 40 AAs). We genotyped 20 OPRM1 markers, 8 OPRD1 markers, and 7 OPRK1 markers, and 38 unlinked ancestry-informative markers in these subjects. The relationships between OPR genes and personality traits were examined using MANCOVA, controlling for gene-gene interaction effects and potential confounders. Associations were decomposed by Roy-Bargmann Stepdown ANCOVA. Personality traits were associated as main or interaction effects with the haplotypes, diplotypes, alleles and genotypes at the three OPR genes (0.002<p<0.046 from MANCOVA; 0.0004<p<0.049 from ANCOVA). Diplotype TTAGGA/TTCAGA at OPRM1 had main effects on Extraversion (p=0.008), and diplotypes OPRM1^TTCAGA/TTCAGA and OPRD1^CAC/TAC had interaction effects on Openness (p=0.010) after conservative correction for multiple testing. The present study demonstrates that the genes encoding the mu-, delta-, and kappa-opioid receptors may contribute to variation in personality traits. Further, the three OPR genes have significant interaction effects on personality traits. This work provides additional evidence that personality traits and SD have a partially overlapping genetic basis.
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影响因子：
56.9
作者：
CLONINGER, CR
通讯作者：
CLONINGER, CR
影响因子：
10.6
作者：
Luo, XG;Klempan, TA;Gelernter, J
通讯作者：
Gelernter, J
影响因子：
2.5
作者：
PRZEWLOCKA, B;LASON, W;PRZEWLOCKI, R
通讯作者：
PRZEWLOCKI, R
影响因子：
6.1
作者：
GIANOULAKIS, C;BARCOMB, A
通讯作者：
BARCOMB, A
影响因子：
11.3
作者：
BLOUIN, AG;PEREZ, EL;BLOUIN, JH
通讯作者：
BLOUIN, JH