5-HT1A receptor activation reduces fear-related behavior following social defeat in Syrian hamsters.
5-HT1A receptor activation reduces fear-related behavior following social defeat in Syrian hamsters.
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DOI：
10.1016/j.pbb.2014.03.024
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发表时间：
2014-07
影响因子：
3.6
通讯作者：
Cooper, Matthew A.
中科院分区：
文献类型：
--
作者：
Bader, Lauren R.;Carboni, Joseph D.;Burleson, Cody A.;Cooper, Matthew A.
社交失败导致选择性地回避熟悉的对手，以及一般性地回避新奇的、没有威胁的入侵者。回避熟悉的对手代表了一种与恐惧有关的记忆，而普遍的社交回避则表明了类似焦虑的行为。我们以前已经表明，5-羟色胺信号改变了叙利亚仓鼠对社会失败的反应，尽管目前还不清楚5-羟色胺是否调节失败引起的恐惧，焦虑，或两者兼而有之。在这项研究中，我们专注于5-HT 1A受体，部分原因是它们的激活与条件恐惧的获得有关。我们假设，在社交失败之前，5-HT 1A受体的药理学激活会减少对熟悉对手的回避，损害基底外侧杏仁核（BLA）中的Arc表达，但不会改变焦虑样行为。我们给仓鼠注射了8-OH-DPAT，一种5-HT 1A受体激动剂，在3分钟、5分钟的社交失败之前，24小时后，将仓鼠暴露于社交互动测试以测量条件性失败反应，随后立即进行Y-迷宫测试或旷场测试。在另一项实验中，我们在3分钟、5分钟社交失败前给予8-OH-DPAT，随后取出大脑进行Arc免疫组织化学。社交失败增加了中央杏仁核（CeA），边缘前皮质（PL）和BLA的Arc免疫阳性细胞的数量，8-OH-DPAT治疗减少了PL的Arc免疫反应性。这些结果表明，5-HT 1A受体激活损害与社交失败相关的恐惧记忆，但不会改变失败引起的焦虑。总体而言，5-HT 1A受体激活可能会损害Arc表达在选择的大脑区域，如PL，从而破坏恐惧记忆的发展必不可少的条件性失败反应。
Social defeat leads to selective avoidance of familiar opponents as well as general avoidance of novel, non-threatening intruders. Avoidance of familiar opponents represents a fear-related memory whereas generalized social avoidance indicates anxiety-like behavior. We have previously shown that serotonin signaling alters responses to social defeat in Syrian hamsters, although it is unclear whether serotonin modulates defeat-induced fear, anxiety, or both. In this study we focus on 5-HT1A receptors, in part, because their activation had been linked to the acquisition of conditioned fear. We hypothesized that pharmacological activation of 5-HT1A receptors prior to social defeat would reduce avoidance of familiar opponents, impair Arc expression in the basolateral amygdala (BLA), but not alter anxiety-like behavior. We administered 8-OH-DPAT, a 5-HT1A receptor agonist, prior to 3, 5-minute social defeats and 24-hours later exposed hamsters to a social interaction test to measure the conditioned defeat response immediately followed by either a Y-maze test or an open field test. In a separate experiment, we administered 8-OH-DPAT prior to 3, 5-minute social defeats and later removed brains for Arc immunohistochemistry. Social defeat increased the number of Arc immunopositive cells in the central amygdala (CeA), prelimbic cortex (PL), and BLA, and 8-OH-DPAT treatment reduced Arc immunoreactivity in the PL. These results suggest that 5-HT1A receptor activation impairs the fear memory associated with social defeat, but does not alter defeat-induced anxiety. Overall, 5-HT1A receptor activation may impair Arc expression in select brain regions such as the PL and thereby disrupt the development of a fear memory essential for the conditioned defeat response.
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影响因子：
1.3
作者：
Huang, Ching-Hsun;Kuo, Ming-Tsung;Lai, Wen-Sung
通讯作者：
Lai, Wen-Sung
影响因子：
3.5
作者：
Huhman, KL;Solomon, MB;Jasnow, AM
通讯作者：
Jasnow, AM
中缝背核中 5-HT1A 自身受体的激活可减少社交失败的行为后果。
影响因子：
3.7
作者：
Cooper, Matthew A.;McIntyre, Kathleen E.;Huhman, Kim L.
通讯作者：
Huhman, Kim L.
DOI：
10.1073/pnas.0909359107
发表时间：
2010-02-09
影响因子：
11.1
作者：
Choi, Dennis C.;Maguschak, Kimberly A.;Ressler, Kerry J.
通讯作者：
Ressler, Kerry J.
影响因子：
1.9
作者：
Jasnow, AM;Shi, C;Huhman, KL
通讯作者：
Huhman, KL