Fetal growth and prenatal exposure to bisphenol A: the generation R study.
Fetal growth and prenatal exposure to bisphenol A: the generation R study.
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DOI：
10.1289/ehp.1205296
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发表时间：
2013-03
影响因子：
10.4
通讯作者：
Burdorf A
中科院分区：
文献类型：
--
作者：
Snijder CA;Heederik D;Pierik FH;Hofman A;Jaddoe VW;Koch HM;Longnecker MP;Burdorf A
背景：产前暴露于双酚A （BPA）与不良出生结局有关，但之前的研究结果并不一致。目的：研究产前BPA暴露与宫内生长的关系，并评估每个受试者的测量次数对观察到的关联的影响。方法：本研究纳入了荷兰一项基于人群的前瞻性队列研究，收集了妊娠早期、中期和晚期的尿液样本。该研究包括219名女性，其中99人进行了一次检测，40人进行了两次检测，80人进行了三次尿液BPA检测。在怀孕期间通过超声波反复测量胎儿的生长特征，并结合出生时的测量。采用线性回归模型对双酚a和胎儿生长进行重复测量，以估计尿中基于肌酐的双酚a （BPACB）浓度与宫内生长之间的关系。结果：BPACB与胎儿生长的关系与每名妇女测量BPA的次数有关。在80名进行了三次BPA测量的妇女中，BPACB浓度为4.22 μg/g crea（肌酐）的妇女的胎儿体重和头围的生长率低于BPACB浓度< 1.54 μg/g crea的妇女，出生时的平均值估计差异分别为-683 g（平均值的20.3%）和-3.9 cm（平均值的11.5%）。当每个妇女可获得的测量数据较少时，暴露-反应关系逐渐减弱，统计上不显著。结论：母体尿中BPA可能影响胎儿生长。由于以前的研究显示了相互矛盾的结果，需要进一步的证据来证实这些发现在一般人群中。
Background: Prenatal exposure to bisphenol A (BPA) has been associated with adverse birth outcomes, but findings of previous studies have been inconsistent. Objective: We investigated the relation of prenatal BPA exposure with intrauterine growth and evaluated the effect of the number of measurements per subject on observed associations. Methods: This study was embedded in a Dutch population-based prospective cohort study, with urine samples collected during early, mid-, and late pregnancy. The study comprised 219 women, of whom 99 had one measurement, 40 had two measurements, and 80 had three measurements of urinary BPA. Fetal growth characteristics were repeatedly measured by ultrasound during pregnancy and combined with measurements at birth. Linear regression models for repeated measurements of both BPA and fetal growth were used to estimate associations between urinary concentrations of creatinine-based BPA (BPACB) and intrauterine growth. Results: The relationship between BPACB and fetal growth was sensitive to the number of BPA measurements per woman. Among 80 women with three BPA measurements, women with BPACB > 4.22 μg/g crea (creatinine) had lower growth rates for fetal weight and head circumference than did women with BPACB < 1.54 μg/g crea, with estimated differences in mean values at birth of –683 g (20.3% of mean) and –3.9 cm (11.5% of mean), respectively. When fewer measurements were available per woman, the exposure–response relationship became progressively attenuated and statistically nonsignificant. Conclusion: Our findings suggest that maternal urinary BPA may impair fetal growth. Because previous studies have shown contradictory findings, further evidence is needed to corroborate these findings in the general population.
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DOI：
10.1093/humrep/der437
发表时间：
2012-03
期刊：
Human reproduction (Oxford, England)
影响因子：
--
作者：
Snijder CA;Roeleveld N;Te Velde E;Steegers EA;Raat H;Hofman A;Jaddoe VW;Burdorf A
通讯作者：
Burdorf A
影响因子：
4.1
作者：
Kuo, HW;Ding, WH
通讯作者：
Ding, WH
关于出生结果和脂肪因子表达的母体和脐带血液中双酚A浓度的生物监测：台湾的一项出生队列研究。
DOI：
10.1186/1476-069x-10-94
发表时间：
2011-11-03
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Chou WC;Chen JL;Lin CF;Chen YC;Shih FC;Chuang CY
通讯作者：
Chuang CY
DOI：
10.1038/jes.2012.39
发表时间：
2012-11-01
影响因子：
4.5
作者：
Koch, Holger M.;Kolossa-Gehring, Marike;Bruening, Thomas
通讯作者：
Bruening, Thomas
DOI：
10.1111/j.1552-6909.2009.01092.x
发表时间：
2010-01-01
影响因子：
1.8
作者：
Gilden, Robyn C.;Huffling, Katie;Sattler, Barbara
通讯作者：
Sattler, Barbara