Metallic Burden of Deciduous Teeth and Childhood Behavioral Deficits.
Metallic Burden of Deciduous Teeth and Childhood Behavioral Deficits.
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DOI：
10.3390/ijerph120606771
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发表时间：
2015-06-15
影响因子：
--
通讯作者：
Ogunseitan OA
中科院分区：
文献类型：
--
作者：
Chan TJ;Gutierrez C;Ogunseitan OA
注意力缺陷/多动障碍(ADHD)在美国影响5%-8%的儿童(10%的男性和4%的女性)。尽管特定的金属通过其神经毒性被认为与儿童行为缺陷有关，但多种金属暴露对儿童行为缺陷的影响尚不清楚。本研究的目的是验证人体锰负荷与ADHD症状呈正相关的假设。我们还研究了钙、铁、铅和汞的可能作用。我们收集了266名儿童(138名男孩和128名女孩)的脱落磨牙，他们在11到13岁之间失去了一颗牙齿。用电感耦合等离子体发射光谱仪分析了磨牙中的金属。每个孩子的三年级老师都完成了老师的破坏性行为评定量表(DBD)，给出了“完全破坏性行为”的分数，以及“注意缺陷多动障碍”、多动/冲动、注意力不集中和对立/挑衅的子量表分数。牙齿中锰、铁、铅、钙的平均含量分别为3.1±2.9、11.4±12.1、0.5±0.7、3.0×105±0.8×105µg/g。未检出汞。未发现锰与行为缺陷之间存在显著关联。CA与多动/冲动、注意力不集中和对立/违抗障碍呈显著负相关，而铅与多动/冲动、注意力不集中和对立/违抗障碍呈显著正相关。当其他金属负荷，特别是钙和铅负荷的平衡起着重要作用时，这些发现质疑了儿童接触锰与行为缺陷之间可能存在的独立联系。
Attention Deficit/Hyperactivity Disorder (ADHD) affects 5%–8% of children in the U.S. (10% of males and 4% of females). The contributions of multiple metal exposures to the childhood behavioral deficits are unclear, although particular metals have been implicated through their neurotoxicity. The objective of this study was to test the hypothesis that the body burden of Mn is positively correlated with ADHD symptoms. We also investigated the putative roles of Ca, Fe, Pb, and Hg. We collected shed molars from 266 children (138 boys and 128 girls) who lost a tooth between 11 and 13 years of age. The molars were analyzed for metals using ICP-OES. The third grade teacher of each child completed the Teacher’s Disruptive Behavior Disorders Rating Scale (DBD) to produce a score for “Total Disruptive Behavior” and subscale scores for “Attention Deficit Hyperactivity Disorder”, Hyperactivity/Impulsivity, Inattention, and Oppositional/Defiant. The mean Mn, Fe, Pb and Ca concentrations found in teeth was 3.1 ± 2.9 µg/g, 11.4 ± 12.1 µg/g, 0.5 ± 0.7 µg/g, and 3.0 × 105 ± 0.8 × 105 µg/g, respectively. Hg was not detected. No significant association was found between Mn and behavioral deficits. Ca was significantly negatively associated, and Pb showed a significant positive association with Hyperactivity/Impulsivity, Inattention, and Oppositional/Defiant Disorders. These findings call into question the putative independent association of manganese exposure and behavioral deficits in children, when the balance of other metallic burden, particularly Ca and Pb burdens play significant roles.
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影响因子：
7
作者：
Flynn, A
通讯作者：
Flynn, A
影响因子：
4.7
作者：
CHANDRA, SV;SHUKLA, GS
通讯作者：
SHUKLA, GS
影响因子：
7.1
作者：
DAVIS, CD;MALECKI, EA;GREGER, JL
通讯作者：
GREGER, JL
影响因子：
64.8
作者：
FOLSOM, TR;JOHNSON, JN;PILLAI, KC
通讯作者：
PILLAI, KC
影响因子：
7.1
作者：
Black, RE;Williams, SM;Goulding, A
通讯作者：
Goulding, A