The integration of negative affect, pain and cognitive control in the cingulate cortex.

The integration of negative affect, pain and cognitive control in the cingulate cortex.
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DOI:
10.1038/nrn2994
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发表时间:
2011-03
影响因子:
34.7
通讯作者:
Davidson, Richard J.
Davidson, Richard J.
中科院分区:
医学1区
文献类型:
--
作者:
Shackman, Alexander J.;Salomons, Tim V.;Slagter, Heleen A.;Fox, Andrew S.;Winter, Jameel J.;Davidson, Richard J.

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有人认为,情绪、疼痛和认知控制在扣带皮层的不同分区中是功能分离的。但最近的观察却鼓励了一种根本不同的观点。影像学研究表明,负面情绪、疼痛和认知控制激活了背扣带的一个重叠区域,即前中扣带皮层(aMCC)。解剖学研究表明,aMCC构成了一个枢纽,在这里,关于情感的信息可以与负责表达情感和执行目标导向行为的运动中心联系起来。计算模型和其他类型的证据表明,这种亲密关系反映了所有三个领域共同的控制过程。这些观察迫使我们重新考虑背扣带回对负面情绪和疼痛的作用。
It has been argued that emotion, pain, and cognitive control are functionally segregated in distinct subdivisions of the cingulate cortex. But recent observations encourage a fundamentally different view. Imaging studies indicate that negative affect, pain, and cognitive control activate an overlapping region of dorsal cingulate, the anterior midcingulate cortex (aMCC). Anatomical studies reveal that aMCC constitutes a hub where information about reinforcers can be linked to motor centers responsible for expressing affect and executing goal-directed behavior. Computational modeling and other kinds of evidence suggest that this intimacy reflects control processes that are common to all three domains. These observations compel a reconsideration of dorsal cingulate’s contribution to negative affect and pain.
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