The integration of negative affect, pain and cognitive control in the cingulate cortex.
The integration of negative affect, pain and cognitive control in the cingulate cortex.
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DOI:
10.1038/nrn2994
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发表时间:
2011-03
影响因子:
34.7
通讯作者:
Davidson, Richard J.
中科院分区:
文献类型:
--
作者:
Shackman, Alexander J.;Salomons, Tim V.;Slagter, Heleen A.;Fox, Andrew S.;Winter, Jameel J.;Davidson, Richard J.
It has been argued that emotion, pain, and cognitive control are functionally segregated in distinct subdivisions of the cingulate cortex. But recent observations encourage a fundamentally different view. Imaging studies indicate that negative affect, pain, and cognitive control activate an overlapping region of dorsal cingulate, the anterior midcingulate cortex (aMCC). Anatomical studies reveal that aMCC constitutes a hub where information about reinforcers can be linked to motor centers responsible for expressing affect and executing goal-directed behavior. Computational modeling and other kinds of evidence suggest that this intimacy reflects control processes that are common to all three domains. These observations compel a reconsideration of dorsal cingulate’s contribution to negative affect and pain.
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