A Multicellular Network Mechanism for Temperature-Robust Food Sensing.
A Multicellular Network Mechanism for Temperature-Robust Food Sensing.
复制标题
一种用于温度鲁棒食物传感的多细胞网络机制。
DOI：
10.1016/j.celrep.2020.108521
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发表时间：
2020-12-22
期刊：
影响因子：
8.8
通讯作者：
Ch'ng Q
中科院分区：
文献类型：
--
作者：
Patel DS;Diana G;Entchev EV;Zhan M;Lu H;Ch'ng Q
对外部线索的反应是生物系统的标志。在复杂的环境中，即使其他内部或外部因素发生波动，生物体也必须对特定输入保持反应。在这里，我们展示了线虫秀丽隐杆线虫如何区分不同的食物水平，以调节其寿命，尽管温度扰动。这种从环境到生理的端到端鲁棒性是由食物感应神经元介导的，这些神经元通过转化生长因子β（TGF-β）和5-羟色胺信号进行通信，以形成多细胞基因网络。该网络中的特定调节随温度改变符号，以保持寿命输出中的类似食物反应。与刻板印象输出的鲁棒性相反，我们的研究结果揭示了一个更复杂的鲁棒性过程，涉及食物反应性的高阶函数。这一过程涉及重新连接多细胞网络以补偿温度，并为理解基因-环境相互作用提供了基础。总之，我们的发现揭示了整合环境线索来管理生理学的感官计算。秀丽隐杆线虫调节寿命以响应食物的能力对温度是鲁棒的鲁棒性需要神经网络中的TGF-β和5-羟色胺信号传导神经网络中的特定调节随温度改变信号温度依赖性调节补偿温度食物和温度都影响寿命，但它们如何相互作用？Patel等人报告说，饮食限制对寿命的影响是强大的温度。这种能力是由食物感觉网络中的温度依赖性可塑性维持的。这种补偿机制保持灵活性和反应能力，尽管外部扰动。
Responsiveness to external cues is a hallmark of biological systems. In complex environments, it is crucial for organisms to remain responsive to specific inputs even as other internal or external factors fluctuate. Here, we show how the nematode Caenorhabditis elegans can discriminate between different food levels to modulate its lifespan despite temperature perturbations. This end-to-end robustness from environment to physiology is mediated by food-sensing neurons that communicate via transforming growth factor β (TGF-β) and serotonin signals to form a multicellular gene network. Specific regulations in this network change sign with temperature to maintain similar food responsiveness in the lifespan output. In contrast to robustness of stereotyped outputs, our findings uncover a more complex robustness process involving the higher order function of discrimination in food responsiveness. This process involves rewiring a multicellular network to compensate for temperature and provides a basis for understanding gene-environment interactions. Together, our findings unveil sensory computations that integrate environmental cues to govern physiology. C. elegans’ ability to modulate lifespan in response to food is robust to temperature Robustness requires TGF-β and serotonin signaling in a neuronal network Specific regulations in the neuronal network change sign with temperature Temperature-dependent regulations compensate for temperature Both food and temperature impact lifespan, but how do they interact? Patel et al. report that the effect of dietary restriction on lifespan is robust to temperature. This ability is sustained by temperature-dependent plasticity in a food-sensory network. Such compensatory mechanisms maintain flexibility and responsiveness despite external perturbations.
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影响因子：
9.8
作者：
Chang AJ;Chronis N;Karow DS;Marletta MA;Bargmann CI
通讯作者：
Bargmann CI
影响因子：
10.9
作者：
Brown, Melissa L.;Schneyer, Alan L.
通讯作者：
Schneyer, Alan L.
影响因子：
5.7
作者：
Cropper EC;Dacks AM;Weiss KR
通讯作者：
Weiss KR
影响因子：
64.5
作者：
Fontana L;Partridge L
通讯作者：
Partridge L
DOI：
10.1073/pnas.231499798
发表时间：
2001-11-20
影响因子：
11.1
作者：
Edelman, GM;Gally, JA
通讯作者：
Gally, JA