The effect of the serotonin transporter polymorphism (5-HTTLPR) on empathic and self-conscious emotional reactivity.
The effect of the serotonin transporter polymorphism (5-HTTLPR) on empathic and self-conscious emotional reactivity.
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DOI：
10.1037/a0029616
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发表时间：
2013-02
期刊：
影响因子：
4.2
通讯作者：
Levenson, Robert W.
中科院分区：
文献类型：
--
作者：
Gyurak, Anett;Haase, Claudia M.;Sze, Jocelyn;Goodkind, Madeleine S.;Coppola, Giovanni;Lane, Jessica;Miller, Bruce L.;Levenson, Robert W.
我们在两项实验室研究中检查了血清素转运蛋白 (5-HTTLPR) 基因的功能多态性与情绪反应个体差异之间的关系。在研究 1 中，评估了三个年龄组的健康成年人对观看其他陷入困境的电影的移情反应和生理反应。在研究 2 中，评估了健康成年人和神经退行性疾病患者看到自己处于尴尬境地时的情绪反应。在研究 1 中，与具有长等位基因的参与者相比，具有两个 5-HTTLPR 短等位基因的参与者报告了更多的个人痛苦，并且对电影表现出更高水平的生理反应。在研究 2 中，与具有长等位基因的参与者相比，具有两个短等位基因的参与者报告了更多的愤怒和娱乐，并在应对尴尬情况时表现出更多的情绪表达行为。来自不同参与者样本的这两项发现共同表明，5-HTTLPR 短等位基因变体纯合的个体在两种截然不同的社会嵌入环境中具有更高水平的情绪反应。
We examined the relationship between a functional polymorphism of the serotonin transporter (5-HTTLPR) gene and individual differences in emotional reactivity in two laboratory studies. In study 1, empathic responding and physiological reactivity to viewing films of others in distress were assessed in healthy adults in three age groups. In study 2, emotional responding to watching oneself in an embarrassing situation was assessed in healthy adults and in patients with neurodegenerative diseases. In study 1, participants with two short alleles of 5-HTTLPR reported more personal distress and showed higher levels of physiological responses in response to the films than participants with long alleles. In study 2, participants with two short alleles reported more anger and amusement and displayed more emotional expressive behaviors in response to the embarrassing situation than participants with long alleles. These two findings from diverse samples of participants converge to indicate that individuals who are homozygous for the short allele variant of 5-HTTLPR have greater levels of emotional reactivity in two quite different socially-embedded contexts.
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影响因子：
2.5
作者：
Furmark, T;Tillfors, M;Fredrikson, M
通讯作者：
Fredrikson, M
影响因子：
4.6
作者：
Beevers, Christopher G.;Wells, Tony T.;McGeary, John E.
通讯作者：
McGeary, John E.
影响因子：
15.1
作者：
Fredericks, Carolyn A.;Drabant, Emily M.;Edge, Michael D.;Tillie, Jean M.;Hallmayer, Joachim;Ramel, Wiveka;Kuo, Janice R.;Mackey, Sean;Gross, James J.;Dhabhar, Firdaus S.
通讯作者：
Dhabhar, Firdaus S.
DOI：
10.1098/rspb.2008.1788
发表时间：
2009-05-22
期刊：
Proceedings. Biological sciences
影响因子：
--
作者：
Fox E;Ridgewell A;Ashwin C
通讯作者：
Ashwin C
影响因子：
4.6
作者：
Beevers, Christopher G.;Marti, C. Nathan;Telch, Michael J.
通讯作者：
Telch, Michael J.