Developmental factors influencing bone strength in precocial mammals: An infant pig model.
Developmental factors influencing bone strength in precocial mammals: An infant pig model.
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大多数脊椎动物在运动方面是早熟的，出生后不久就能行走和奔跑。早睡症需要骨骼有足够的强度来抵抗早期运动过程中的机械负荷。本研究的目的是使用一个动物模型-早产仔猪-来调查一些可能决定早熟动物骨强度变化的近似因素。基于先前的文献，我们检验了骨骼完整性将因妊娠缩短而显著受损的无效预测（即，早产）和出生时体重减少。我们生成了一套早产和足月幼猪无骨骨骼的形态测量指标（组织矿物质密度和横截面几何形状）和性能相关指标（三点弯曲试验期间抵抗载荷、变形和断裂的能力）。结果表明，在我们的个体发育幼猪样本中，很少有措施显着变化，无论是妊娠期长短或出生质量。总的来说，我们的研究结果有助于越来越多的文献证明早熟婴儿肌肉骨骼系统的早期功能能力，并表明围产期早熟哺乳动物的骨强度可能是强大的因素，以损害骨骼完整性，在更多的altricial类群。我们收集了一套早产和足月仔猪的骨强度的形态测量和性能相关指标，检验了婴儿骨骼完整性将因妊娠期缩短而显著受损的假设（即，早产）和出生时体重减少。结果表明，在我们的个体发育幼猪样本中，很少有措施显着变化与妊娠期长短或出生质量，这表明婴儿早熟哺乳动物的骨强度可能是强大的因素，以损害骨骼完整性，在更多的altricial类群。
Most vertebrates are precocial in locomotion, able to walk and run soon after birth. Precociality requires a bony skeleton of sufficient strength to resist mechanical loading during early locomotor efforts. The aim of this study was to use an animal model—the preterm infant pig—to investigate some of the proximate factors that might determine variation in bone strength in precocial animals. Based on the prior literature, we tested the null predictions that skeletal integrity would be significantly compromised by truncated gestation (i.e., preterm birth) and reduced body mass at birth. We generated a suite of both morphometric measures (tissue mineral density and cross‐sectional geometry) and performance‐related metrics (ability to resist loading, deformation, and fracture during three‐point bending tests) of the appendicular skeleton of preterm and full‐term infant pigs. Results showed that very few measures in our ontogenetic infant pig sample significantly varied with either gestation length or birth mass. Overall, our results contribute to a growing body of literature demonstrating the early functional capacity of the precocial infant musculoskeletal system and suggest that bone strength in perinatal precocial mammals may be robust to the factors shown to compromise skeletal integrity in more altricial taxa. We collected a suite of morphometric and performance‐related metrics of appendicular bone strength in preterm and full‐term infant pigs, testing the hypothesis that infant skeletal integrity would be significantly compromised by truncated gestation (i.e., preterm birth) and reduced body mass at birth. Results showed that very few measures in our ontogenetic infant pig sample significantly varied with either gestation length or birth mass, suggesting that bone strength in infant precocial mammals may be robust to the factors shown to compromise skeletal integrity in more altricial taxa.
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影响因子：
1.7
作者：
Chen, Hsiu-Lin;Lee, Chia-Ling;Jao, Hsiao-Ching
通讯作者：
Jao, Hsiao-Ching
影响因子：
2.6
作者：
Ballester A;Gould F;Bond L;Stricklen B;Ohlemacher J;Gross A;DeLozier K;Buddington R;Buddington K;Danos N;German R
通讯作者：
German R
影响因子：
3.6
作者：
Bowden, LS;Jones, CJ;Ryan, SW
通讯作者：
Ryan, SW
影响因子：
--
作者：
Erickson, GM;Catanese, J;Keaveny, TM
通讯作者：
Keaveny, TM
影响因子：
7.3
作者：
Baek, Ole;Sangild, Per Torp;Duc Ninh Nguyen
通讯作者：
Duc Ninh Nguyen