Amine trapping: physical explanation for the inhibitory effect of gastric acidity on the postprandial release of gastrin. Studies on rats and dogs.
Amine trapping: physical explanation for the inhibitory effect of gastric acidity on the postprandial release of gastrin. Studies on rats and dogs.
复制标题
胺捕获：胃酸度对餐后胃泌素释放抑制作用的物理解释。
DOI：
10.1016/0016-5085(86)90389-6
复制
发表时间：
1986
期刊：
影响因子：
29.4
通讯作者：
Graziani,LA
中科院分区：
文献类型：
--
作者：
Lichtenberger,LM;Nelson,AA;Graziani,LA
我们研究了膳食刺激胃泌素释放的 pH 依赖性与胃窦粘膜对膳食胺的渗透性之间的关系。这项研究是在我们实验室之前的工作证明膳食胺在体内和体外是胃泌素释放的有效刺激物之后进行的，并且已经确定胺被困在酸性环境中。采用三个对比实验模型系统来研究这两种 pH 依赖性特性的关联。第一项体内研究表明，摄入标准大鼠食物会导致循环胃泌素和氨水平增加，而如果大鼠摄入预先酸化至 pH 值 2.4 的食物，这两种特性的餐后增加就会被消除。其次，通过荧光显微镜和分光光度法监测幽门结扎大鼠胃腔对荧光环胺奎纳克林的胃窦摄取，并证明随着胃腔 pH 值的降低，胃窦对荧光环胺奎纳克林的摄取受到逐步抑制。最后，我们的体外研究表明，[14C]甲胺转运到安装在尤斯室中的犬胃窦粘膜中是pH依赖性的，胃泌素释放到培养介质中也是如此。因此，所有数据都与膳食刺激的胃泌素释放在低pH值下受到抑制的可能性一致，部分原因是膳食胺的质子化，阻止它们扩散到G细胞中以激活激素分泌。
We investigated the relationship between the pH dependence of meal-stimulated gastrin release and the permeability of the antral mucosa to dietary amines. This study was undertaken after previous work from our laboratory had demonstrated that dietary amines are potent in vivo and in vitro stimulants of gastrin release and that it is well established that amines are trapped in acidic environments. Three contrasting experimental model systems were employed to investigate the association of these two pH-dependent properties. In the first in vivo study, it was demonstrated that ingestion of standard rat Chow resulted in an increase in circulating gastrin and ammonia levels, whereas the postprandial increases in both properties were abolished if the rats ingested Chow that was preacidified to a pH of 2.4. Second, the antral uptake of the fluorescent cyclic amine, quinacrine, from the gastric lumen of pylorus-ligated rats was monitored by fluorescent microscopy and spectrophotometry and was demonstrated to be inhibited in a step-wise fashion as the luminal pH was decreased. Lastly, our in vitro studies suggested that the transport of [14C]methylamine into canine antral mucosa mounted in Ussing chambers was pH-dependent, as was gastrin release into the incubation medium. Thus, all the data are consistent with the possibility that meal-stimulated gastrin release is inhibited at low pH, due (in part) to the protonation of dietary amines, preventing their diffusion into the G cell to activate hormone secretion.
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正常和溃疡受试者中酸分泌和胃泌素释放的 pH 依赖性。
影响因子：
15.9
作者：
J. Walsh;C. T. Richardson;J. Fordtran
通讯作者：
J. Fordtran
用于放射免疫分析的 125 I 标记的合成人胃泌素 I 的制备。
DOI：
10.3109/00365517209080271
发表时间：
1972
影响因子：
2.1
作者：
F. Stadil;J. Rehfeld
通讯作者：
J. Rehfeld
假喂养刺激的胃泌素释放和胃酸分泌的酸抑制：阿托品的作用。
影响因子：
29.4
作者：
M. Feldman;J. Walsh
通讯作者：
J. Walsh
食品中的胺。
DOI：
10.1080/10408397809527256
发表时间：
1978
期刊：
CRC critical reviews in food science and nutrition
影响因子：
--
作者：
J. Maga
通讯作者：
J. Maga
胃窦的空间关系在狗胃空肠溃疡发展中的重要性。
DOI：
10.1007/s11033-004-0566-3
发表时间：
1953
期刊：
Surgical forum
影响因子：
--
作者：
W. D. Kelly;F. S. Cross;O. Wangensteen
通讯作者：
O. Wangensteen