Parental care influences leukocyte telomere length with gender specificity in parents and offsprings.
Parental care influences leukocyte telomere length with gender specificity in parents and offsprings.
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DOI：
10.1186/s12888-014-0277-9
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发表时间：
2014-10-03
期刊：
影响因子：
4.4
通讯作者：
Otani K
中科院分区：
文献类型：
--
作者：
Enokido M;Suzuki A;Sadahiro R;Matsumoto Y;Kuwahata F;Takahashi N;Goto K;Otani K
有一些报告表明，不良的童年经历，如身体虐待和长期的制度化影响端粒长度。然而，还没有研究端粒长度与父母养育方式的关系。在本研究中，我们研究了健康受试者白细胞端粒长度与父母养育方式的关系。受试者为581名无关的健康日本受试者。父母教养方式采用父母教养方式量表（Parental Bonding Instrument）进行评估，该量表包括照顾和保护因素。白细胞相对端粒长度通过定量实时PCR方法测定端粒/单拷贝基因的比率。在多元回归分析中，男性端粒长度越短，其父亲照料得分越低（β = 0.139，p < 0.05），而女性端粒长度越短，其母亲照料得分越低（β = 0.195，p < 0.01）。本研究结果表明，父母的照料与端粒长度之间存在线性关系，父母的照料对端粒长度的影响具有性别特异性。
There have been several reports suggesting that adverse childhood experiences such as physical maltreatment and long institutionalization influence telomere length. However, there has been no study examining the relationship of telomere length with variations in parental rearing. In the present study, we examined the relationship of leukocyte telomere length with parental rearing in healthy subjects. The subjects were 581 unrelated healthy Japanese subjects. Perceived parental rearing was assessed by the Parental Bonding Instrument consisting of the care and protection factors. Leukocyte relative telomere length was determined by a quantitative real-time PCR method for a ratio of telomere/single copy gene. In the multiple regression analyses, shorter telomere length in males was related to lower scores of paternal care (β = 0.139, p < 0.05), while that in females was related to lower scores of maternal care (β = 0.195, p < 0.01). The present study suggests that there is linear relationship between parental care and telomere length which covers both lower and higher ends of parental care, and that the effects of parental care on telomere length are gender-specific in parents and offsprings.
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影响因子：
3.3
作者：
Almeida ND;Loucks EB;Kubzansky L;Pruessner J;Maselko J;Meaney MJ;Buka SL
通讯作者：
Buka SL
影响因子：
11
作者：
Drury SS;Theall K;Gleason MM;Smyke AT;De Vivo I;Wong JY;Fox NA;Zeanah CH;Nelson CA
通讯作者：
Nelson CA
影响因子：
3.4
作者：
Agostini, Alessandro;Rizzello, Fernando;Campieri, Massimo
通讯作者：
Campieri, Massimo
影响因子：
1.5
作者：
Engert, Veronika;Buss, Claudia;Pruessner, Jens C.
通讯作者：
Pruessner, Jens C.
影响因子：
7.6
作者：
Lee, Royce J.;Gollan, Jackie;Coccaro, Emil F.
通讯作者：
Coccaro, Emil F.