Metabolic regulation of brain response to food cues.
Metabolic regulation of brain response to food cues.
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DOI：
10.1016/j.cub.2013.04.001
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发表时间：
2013-05-20
期刊：
影响因子：
9.2
通讯作者：
Small, Dana M.
中科院分区：
文献类型：
--
作者：
de Araujo, Ivan E.;Lin, Tammy;Veldhuizen, Maria G.;Small, Dana M.
能量来源的识别取决于在食物线索和营养价值之间形成联系的能力。因此，先前与卡路里配对的线索会引起伏隔核（NAcc）的神经元激活，这反映了食物的强化价值。调节这种反应的生理信号的身份仍然难以捉摸。使用功能磁共振成像，我们检查了大脑对前几天食用的无热量口味的反应，这些口味的热量为0或112.5卡路里，来自未检测到的麦芽糊精。我们报告了对与卡路里配对的味道的喜爱程度的小幅但有意义的增加，并发现喜欢程度的变化与对这种饮料的岛屿反应的变化有关。相比之下，NAcc和下丘脑对与卡路里配对的味道的反应与喜欢无关，但与之前摄入卡路里饮料时摄入的血浆葡萄糖水平的变化密切相关。重要的是，由于每个参与者摄入相同的热量剂量，血浆葡萄糖的变化取决于葡萄糖代谢的个体差异。我们得出的结论是，葡萄糖代谢是调节NAcc和下丘脑对食物线索反应的关键信号，并且这一过程独立于卡路里调节喜好的能力。
Identification of energy sources depends upon the ability to form associations between food cues and nutritional value. As such, cues previously paired with calories elicit neuronal activation in the nucleus accumbens (NAcc), which reflects the reinforcing value of food. The identity of the physiological signals regulating this response remains elusive. Using fMRI, we examined brain response to noncaloric versions of flavors that had been consumed in previous days with either 0 or 112.5 calories from undetected maltodextrin. We report a small but perceptually meaningful increase in liking for the flavor that had been paired with calories and find that change in liking was associated with changes in insular responses to this beverage. In contrast, NAcc and hypothalamic response to the calorie-paired flavor was unrelated to liking but was strongly associated with the changes in plasma glucose levels produced by ingestion of the beverage when consumed previously with calories. Importantly, because each participant ingested the same caloric dose, the change in plasma glucose depended upon individual differences in glucose metabolism. We conclude that glucose metabolism is a critical signal regulating NAcc and hypothalamic response to food cues, and that this process operates independently from the ability of calories to condition liking.
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