Cold pressor pain assessment based on EEG power spectrum

Cold pressor pain assessment based on EEG power spectrum
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基于EEG功率谱的冷压疼痛评估

DOI:
10.1007/s42452-020-03822-8
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发表时间:
2020
影响因子:
2.6
通讯作者:
Lin, Yingzi
Lin, Yingzi
中科院分区:
--
文献类型:
--
作者:
Wang, Li;Xiao, Yan;Urman, Richard D.;Lin, Yingzi

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病人的疼痛程度是影响麻醉药使用的一个基本因素。为探讨冷加压痛时脑电的频域反应,记录了20名健康受试者在冷加压试验中的脑电信号。采用带通滤波和独立分量分析对脑电信号进行预处理。快速傅立叶变换用于脑电功率谱分析。对EEG功率进行配对t检验,以研究疼痛和非疼痛EEG功率之间差异的显著性。在疼痛状态下,EEG通道位置Cz、O1和O2处的EEG功率在大多数频带上显著增加:1 - 4Hz、4 - 8Hz、8 - 13Hz、13 - 30Hz、30 - 50Hz。在疼痛条件下,γ波段的EEG功率在广泛的脑区域上增加。这项研究表明,在疼痛状态下的EEG数据的功率在大多数频带上具有较高的值。中枢和枕叶脑区在无疼痛和疼痛状态之间显示出最显著的差异。这项研究的结果提供了证据,脑电图是一个有前途的工具,以客观地评估人类的疼痛水平。
Patients’ pain level of the patients is a fundamental factor for the patients’ anesthetics usage. To investigate the responses of electroencephalogram (EEG) to cold pressor pain in the frequency domain, twenty healthy subjects’ EEG signals were recorded during a cold pressor test. A band-pass filter and independent component analysis were used to preprocess the EEG signal. Fast Fourier transformation as used to analyze the EEG power spectrum. Paired t-tests were performed on the EEG power to investigate the significance of the difference between pain and no-pain EEG power. In pain state, the EEG power increased significantly at EEG channel location Cz, O1, and O2 over most frequency bands: 1–4 Hz, 4–8 Hz, 8–13 Hz, 13–30 Hz, 30–50 Hz. The EEG power of the gamma band increased over extensive brain regions in pain condition. This study suggests that the power of EEG data in pain state has a higher value over most frequency bands. The central and occipital brain regions show the most significant differences between no-pain and pain state. The findings of this study provide evidence that EEG is a promising tool to objectively assess the pain level of human beings.
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