Differences in glucose tolerance between deficit and nondeficit schizophrenia.
Differences in glucose tolerance between deficit and nondeficit schizophrenia.
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DOI：
10.1016/j.schres.2008.09.023
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发表时间：
2009-02
影响因子：
4.5
通讯作者：
Bernardo, Miguel
中科院分区：
文献类型：
--
作者：
Kirkpatrick, Brian;Fernandez-Egea, Emilio;Garcia-Rizo, Clemente;Bernardo, Miguel
一些研究表明，精神分裂症与糖尿病风险的增加有关，独立于抗精神病药物的使用。缺陷型精神分裂症以原发(或特发性)、持久的阴性症状为特征，在病程、治疗反应、危险因素和生物学相关因素上与非缺陷型精神分裂症不同。我们假设缺陷和非缺陷受试者在糖耐量方面也会有所不同。新诊断的非情感性精神病的抗精神病药物天真的受试者和匹配的对照组受试者接受75g口服葡萄糖耐量试验(GTT)。非缺陷组(N=23；平均[SD]为121.6[42.0])的2小时血糖浓度显著高于缺陷组(N=23；100.2[23.1])和对照组(N=59；83.8[2 1.9])；缺陷组的2小时血糖浓度也显著高于对照组。这些结果进一步支持了缺陷组具有独特的病因生理学。
Some studies suggest that schizophrenia is associated with an increased risk of diabetes independently of antipsychotic use. People with deficit schizophrenia, which is characterized by primary (or idiopathic), enduring negative symptoms, differ from those with nondeficit schizophrenia on course of illness, treatment response, risk factors, and biological correlates. We hypothesized that deficit and nondeficit subjects would also differ with regard to glucose tolerance. Newly diagnosed, antipsychotic-naïve subjects with nonaffective psychosis and matched control subjects were administered a 75 g oral glucose tolerance test (GTT). Two-hour glucose concentrations were significantly higher in the nondeficit patients (N=23; mean [SD] of 121.6 [42.0]) than in deficit (N=23; 100.2 [23.1]) and control subjects (N=59; 83.8 [21.9]); the deficit subjects also had significantly higher two-hour glucose concentrations than did the control subjects. These results provide further support that the deficit group has a distinctive etiopathophysiology.
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DOI：
10.1001/archneurpsyc.1946.02300180084007
发表时间：
1946-01-01
影响因子：
--
作者：
FREEMAN, H
通讯作者：
FREEMAN, H
影响因子：
--
作者：
Kirkpatrick, B;Buchanan, RW;Carpenter, WT
通讯作者：
Carpenter, WT
影响因子：
4.5
作者：
Kirkpatrick, B;Amador, XF;McGlashan, T
通讯作者：
McGlashan, T
影响因子：
6.6
作者：
Dickerson, F;Kirkpatrick, B;Yolken, R
通讯作者：
Yolken, R
影响因子：
4.5
作者：
Femandez-Egea, Emilio;Miller, Brian;Kirkpatrick, Brian
通讯作者：
Kirkpatrick, Brian