Neurophysiological indices of atypical auditory processing and multisensory integration are associated with symptom severity in autism.
Neurophysiological indices of atypical auditory processing and multisensory integration are associated with symptom severity in autism.
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DOI：
10.1007/s10803-014-2212-9
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发表时间：
2015-01
影响因子：
3.9
通讯作者：
Molholm, Sophie
中科院分区：
文献类型：
--
作者：
Brandwein, Alice B.;Foxe, John J.;Butler, John S.;Frey, Hans-Peter;Bates, Juliana C.;Shulman, Lisa H.;Molholm, Sophie
感觉输入的非典型加工和整合被假设在自闭症谱系障碍（ASD）的异常感觉反应和社会认知缺陷中发挥作用。然而，关于感觉处理的客观指标与临床症状之间关系的报告却令人惊讶地稀少。在这里，我们研究了感觉处理的神经生理学测定与1）自闭症严重程度和2）感觉敏感性之间的关系，在6-17岁的ASD患者中。多元线性回归表明听觉处理和多感觉整合的神经标记物与自闭症严重程度之间存在显着关联。对于视觉/听觉灵敏度的临床测量，没有明显的这种关系。这些数据支持异常的早期感觉处理有助于自闭症症状，并揭示了电生理学客观分型自闭症的潜力。
Atypical processing and integration of sensory inputs are hypothesized to play a role in unusual sensory reactions and social-cognitive deficits in autism spectrum disorder (ASD). Reports on the relationship between objective metrics of sensory processing and clinical symptoms, however, are surprisingly sparse. Here we examined the relationship between neurophysiological assays of sensory processing and 1) autism severity and 2) sensory sensitivities, in individuals with ASD aged 6–17. Multiple linear regression indicated significant associations between neural markers of auditory processing and multisensory integration, and autism severity. No such relationships were apparent for clinical measures of visual/auditory sensitivities. These data support that aberrant early sensory processing contributes to autism symptoms, and reveal the potential of electrophysiology to objectively subtype autism.
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影响因子：
1.9
作者：
Casanova, MF;Buxhoeveden, DP;Brown, C
通讯作者：
Brown, C
影响因子：
4.7
作者：
Ceponiene, R;Rinne, T;Näätänen, R
通讯作者：
Näätänen, R
影响因子：
6.9
作者：
Charman, T.;Pickles, A.;Baird, G.
通讯作者：
Baird, G.
影响因子：
25.8
作者：
Cardinale, Ryan C.;Shih, Patricia;Fishman, Inna;Ford, Leanne M.;Mueller, Ralph-Axel
通讯作者：
Mueller, Ralph-Axel
影响因子：
3.9
作者：
COURCHESNE, E;LINCOLN, AJ;GALAMBOS, R
通讯作者：
GALAMBOS, R