The mtDNA haplogroup P of modern Asian cattle: A genetic legacy of Asian aurochs?
The mtDNA haplogroup P of modern Asian cattle: A genetic legacy of Asian aurochs?
复制标题
DOI：
10.1371/journal.pone.0190937
复制
发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Mannen H
中科院分区：
文献类型：
--
作者：
Noda A;Yonesaka R;Sasazaki S;Mannen H
在更新世晚期和全新世早期，欧洲野牛（Bos aurochus）分布于欧亚大陆和北方非洲的大部分地区，所有现代牛都是从欧洲野牛进化而来的。虽然大多数现代牛的mtDNA单倍群属于单倍群T和I，但在现代牛和欧洲野牛中还发现了几个额外的单倍群（P，Q，R，C和E）。单倍群P是欧洲野牛中最常见的单倍群，但到目前为止，在超过3，000个提交的现代亚洲牛单倍型中只有3个被鉴定出。我们对181头日本短角牛的线粒体DNA D环区进行了全序列测定，并与代表性的牛线粒体DNA序列一起进行了分析。日本短角牛的单倍型P进行了分析沿着与36个以前发表的欧洲欧洲野牛和三个现代亚洲牛序列使用高变410 bp的D-环区。我们在日本短角牛中以极高的频率（83/181）检测到线粒体DNA单倍群P。系统发生网络揭示了两个主要的集群，指定为Pa的单倍群P在欧洲欧洲野牛和Pc在现代亚洲牛。我们还报告了单倍群P的遗传多样性与灭绝的欧洲野牛的序列相比。欧洲野牛和现代亚洲牛之间没有观察到共享的单倍型。这一发现表明，在东北亚牛的单倍群P的本地和二次渐渗事件的可能性，并将有助于更好地了解其起源和遗传多样性。
Aurochs (Bos primigenius) were distributed throughout large parts of Eurasia and Northern Africa during the late Pleistocene and the early Holocene, and all modern cattle are derived from the aurochs. Although the mtDNA haplogroups of most modern cattle belong to haplogroups T and I, several additional haplogroups (P, Q, R, C and E) have been identified in modern cattle and aurochs. Haplogroup P was the most common haplogroup in European aurochs, but so far, it has been identified in only three of >3,000 submitted haplotypes of modern Asian cattle. We sequenced the complete mtDNA D-loop region of 181 Japanese Shorthorn cattle and analyzed these together with representative bovine mtDNA sequences. The haplotype P of Japanese Shorthorn cattle was analyzed along with that of 36 previously published European aurochs and three modern Asian cattle sequences using the hypervariable 410 bp of the D-loop region. We detected the mtDNA haplogroup P in Japanese Shorthorn cattle with an extremely high frequency (83/181). Phylogenetic networks revealed two main clusters, designated as Pa for haplogroup P in European aurochs and Pc in modern Asian cattle. We also report the genetic diversity of haplogroup P compared with the sequences of extinct aurochs. No shared haplotypes are observed between the European aurochs and the modern Asian cattle. This finding suggests the possibility of local and secondary introgression events of haplogroup P in northeast Asian cattle, and will contribute to a better understanding of its origin and genetic diversity.
登录
查看更多内容
影响因子：
3.7
作者：
Bonfiglio S;Achilli A;Olivieri A;Negrini R;Colli L;Liotta L;Ajmone-Marsan P;Torroni A;Ferretti L
通讯作者：
Ferretti L
影响因子：
10.7
作者：
TAMURA, K;NEI, M
通讯作者：
NEI, M
影响因子：
3.7
作者：
Ajmone-Marsan, Paolo;Garcia, Jose Fernando;Lenstra, Johannes A.
通讯作者：
Lenstra, Johannes A.
影响因子：
10.7
作者：
SAITOU, N;NEI, M
通讯作者：
NEI, M
影响因子：
10.7
作者：
Chen, Shanyuan;Lin, Bang-Zhong;Beja-Pereira, Albano
通讯作者：
Beja-Pereira, Albano