High-definition transcranial direct current stimulation modulates theta response during a Go-NoGo task in traumatic brain injury.
High-definition transcranial direct current stimulation modulates theta response during a Go-NoGo task in traumatic brain injury.
复制标题
DOI：
10.1016/j.clinph.2022.08.015
复制
发表时间：
2022-11
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
高清晰度经颅直流电刺激（HD-tDCS）已被证明可以改善慢性创伤性脑损伤（TBI）患者的认知能力，尽管电生理机制尚不清楚。创伤性脑损伤退伍军人接受了针对前辅助运动区（前sma）的活跃阳极（N = 15）和假（N = 10） HD-tDCS。Go-NoGo任务在基线和干预完成后与脑电图（EEG）同时进行。我们发现，在主动HD-tDCS干预后，在前sma上的额叶中线电极上，Go期间的θ事件相关谱扰动（ERSP）和试验间相相干性（ITPC）增加，但假手术后没有增加。我们还发现，激活HD-tDCS后，Go期间额叶中线和左后脑区域之间的θ相相干性增加。在活跃的HD-tDCS后，发现左中央区α - θ ERSP晚期增加。值得注意的是，只有在活动组，较低的额中线区域基线θ ERSP/ITPC预示着干预后围棋成绩的改善。在慢性脑外伤中，HD-tDCS调节反应存在局部和区域间振荡变化。这些发现可以指导未来利用脑电图时频指标的研究，不仅可以测量介入效果，还可以选择可能对治疗有最佳反应的候选人。
High Definition transcranial Direct Current Stimulation (HD-tDCS) has been shown to improve cognitive performance in individuals with chronic traumatic brain injury (TBI), although electrophysiological mechanisms remain unclear. Veterans with TBI underwent active anodal (N = 15) vs sham (N = 10) HD-tDCS targeting the pre-supplementary motor area (pre-SMA). A Go-NoGo task was conducted simultaneously with electroencephalography (EEG) at baseline and after intervention completion. We found increased theta event-related spectral perturbation (ERSP) and inter-trial phase coherence (ITPC) during Go in the frontal midline electrodes overlying the pre-SMA after active HD-tDCS intervention, but not after sham. We also found increased theta phase coherence during Go between the frontal midline and left posterior regions after active HD-tDCS. A late increase in alpha-theta ERSP was found in the left central region after active HD-tDCS. Notably, lower baseline theta ERSP/ITPC in the frontal midline region predicted more post-intervention improvement in Go performance only in the active group. There are local and interregional oscillatory changes in response to HD-tDCS modulation in chronic TBI. These findings may guide future research in utilizing EEG time-frequency metrics not only to measure interventional effects, but also in selecting candidates who may optimally respond to treatment.
登录
查看更多内容
影响因子：
3.4
作者：
Chiang HS;Shakal S;Vanneste S;Kraut M;Hart J Jr
通讯作者：
Hart J Jr
影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
影响因子：
3
作者：
Bastos AM;Schoffelen JM
通讯作者：
Schoffelen JM
DOI：
10.3390/diagnostics11040627
发表时间：
2021-03-31
期刊：
Diagnostics (Basel, Switzerland)
影响因子：
--
作者：
Hara T;Shanmugalingam A;McIntyre A;Burhan AM
通讯作者：
Burhan AM
影响因子：
2.5
作者：
Chiang, Hsueh-Sheng;Motes, Michael;Hart, John Jr Jr
通讯作者：
Hart, John Jr Jr