Facial intramuscular lipoma occurrence following topical cosmetic injection with a mixture of basic fibroblast growth factor: A report of two cases
Facial intramuscular lipoma occurrence following topical cosmetic injection with a mixture of basic fibroblast growth factor: A report of two cases
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局部注射碱性成纤维细胞生长因子混合液后发生面部肌内脂肪瘤二例报告
DOI：
10.1080/14764172.2017.1293827
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发表时间：
2017-02
影响因子：
1.2
通讯作者：
Liu Hong-Wei
中科院分区：
文献类型：
--
作者：
Liao Xuan;Zhang Zhi-Dan;Li Sheng-Hong;Xiao Li-Ling;Lu Jin-Qiang;Xie Bo;Liu Hong-Wei
摘要 生长因子和细胞因子通过细胞间和细胞内信号通路网络控制细胞生长、增殖和分化，并参与皮肤自我更新和伤口愈合。近年来，局部和注射生长因子和细胞因子已成为一种有趣的治疗方式，可用于美容目的。然而，关于其长期安全性和耐受性的数据很少。在本报告中，我们描述了两例患者，他们在局部注射碱性成纤维细胞生长因子混合物作为隆下巴的主要成分后，出现了下巴肌内脂肪瘤。两例均在我科进行活检，结果显示为肌内脂肪瘤。我们的报告表明，局部注射生长因子可能导致肿瘤发生，因此医疗保健提供者需要意识到其潜在后果。
ABSTRACT Growth factors and cytokines control cell growth, proliferation and differentiation via a network of inter- and intracellular signalling pathways, and are involved in skin self-renewing and wound healing. In recent years, topical and injectable growth factors and cytokines have emerged as an intriguing therapeutic modality that can be harnessed for aesthetic purposes. However, very little data are available on their long-term safety and tolerability. In this report, we describe two cases of patients, who developed intramuscular lipoma of the chin following topical injection with a mixture of basic fibroblast growth factor as the main ingredients for chin augmentation. Biopsies in the two cases were performed at our department, and revealed intramuscular lipoma. Our report indicates that the topical injection of growth factors can lead to tumorigenesis, so health care providers need to be aware of its potential consequences.
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通讯作者：
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影响因子：
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