Leukocyte telomere length in healthy Caucasian and African-American adolescents: relationships with race, sex, adiposity, adipokines, and physical activity.
Leukocyte telomere length in healthy Caucasian and African-American adolescents: relationships with race, sex, adiposity, adipokines, and physical activity.
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DOI：
10.1016/j.jpeds.2010.08.007
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发表时间：
2011-02
期刊：
影响因子：
--
通讯作者：
Dong Y
中科院分区：
文献类型：
--
作者：
Zhu H;Wang X;Gutin B;Davis CL;Keeton D;Thomas J;Stallmann-Jorgensen I;Mooken G;Bundy V;Snieder H;van der Harst P;Dong Y
To examine the relations of race, sex, adiposity, adipokines and physical activity to telomere length in adolescents. Leukocyte telomere length (T/S ratio) was assessed cross-sectionally in 667 adolescents (aged 14–18 years, 48% blacks, 51% girls) using a quantitative PCR method. Generalized Estimating Equations analyses were performed. Black adolescents had longer telomeres than white adolescents (age and sex adjusted T/S ratio ± SE: 1.32 ± 0.01 vs. 1.27 ± 0.01, p=0.014) and girls had longer telomeres than boys (age and race adjusted T/S ratio ± SE: 1.31 ± 0.01 vs. 1.27 ± 0.01, p=0.007). None of the adiposity or adipokine measures explained a significant proportion of the variance in telomere length. Vigorous physical activity was positively associated with telomere length (adjusted R2=0.019, p=0.009) and accounted for 1.9% of the total variance only in girls. This study, conducted in a biracial adolescent cohort, demonstrated that: (1) race and sex differences in telomere length have already emerged during adolescence; (2) adiposity and adipokines are not associated with telomere length at this age; and (3) the anti-aging effect of vigorous physical activity may begin in youth especially in girls.
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DOI：
10.1158/1055-9965.epi-08-0935
发表时间：
2009-03
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Kim S;Parks CG;DeRoo LA;Chen H;Taylor JA;Cawthon RM;Sandler DP
通讯作者：
Sandler DP
影响因子：
8.3
作者：
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通讯作者：
Aviv, A
DOI：
10.1249/mss.0b013e31819ca063
发表时间：
2009-08-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Mandic, Sandra;Myers, Jonathan N.;Froelicher, Victor F.
通讯作者：
Froelicher, Victor F.
影响因子：
30.8
作者：
通讯作者：
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影响因子：
8.3
作者：
Benetos, A;Okuda, K;Aviv, A
通讯作者：
Aviv, A