Altered resting-state functional connectivity within corticostriatal and subcortical-striatal circuits in chronic pain.
Altered resting-state functional connectivity within corticostriatal and subcortical-striatal circuits in chronic pain.
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DOI：
10.1038/s41598-022-16835-7
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发表时间：
2022-07-25
影响因子：
4.6
通讯作者：
Martucci, Katherine T.
中科院分区：
文献类型：
--
作者：
Park, Su Hyoun;Baker, Anne K.;Krishna, Vinit;Mackey, Sean C.;Martucci, Katherine T.
大脑皮质纹状体回路对于理解慢性疼痛很重要，并且与动机和认知过程高度相关。已经证明，在慢性背痛患者中，基于功能磁共振成像的伏隔核 (NAcc) 内侧前额皮质 (MPFC) 回路活动的改变可以预测患者的预后。我们评估了患有另一种慢性疼痛（纤维肌痛）的患者的 NAcc-MPFC 回路，以扩展这些重要的发现。首先，我们比较了纤维肌痛患者 (N = 32) 与健康对照 (N = 37) 的基于 fMRI 的 NAcc-MPFC 静息态功能连接。与对照组相比，纤维肌痛患者的 NAcc-MPFC 回路连接性显着降低。此外，在纤维肌痛组中，NAcc-MPFC 连接与特质焦虑显着相关。我们对 NAcc 与皮层下大脑区域的扩展连接性分析显示，纤维肌痛中右侧 NAcc 与中脑边缘回路区域（壳核、丘脑和腹侧苍白球）的连接性降低。最后，在一项探索性分析中，将我们的纤维肌痛组和健康对照队列与来自慢性背痛患者的单独公开数据集进行比较，我们发现两个患者组的 NAcc-MPFC 连接性均降低，并且 NAcc-中脑边缘连接性发生了独特的改变。总之，我们的研究结果扩展了先前观察到的大脑皮质纹状体回路的变化，为慢性疼痛中皮质纹状体和中脑边缘回路的改变提供了新的证据。
Brain corticostriatal circuits are important for understanding chronic pain and highly relevant to motivation and cognitive processes. It has been demonstrated that in patients with chronic back pain, altered nucleus accumbens (NAcc)—medial prefrontal cortex (MPFC) circuit fMRI-based activity is predictive of patient outcome. We evaluated the NAcc-MPFC circuit in patients with another chronic pain condition, fibromyalgia, to extend these important findings. First, we compared fMRI-based NAcc-MPFC resting-state functional connectivity in patients with fibromyalgia (N = 32) vs. healthy controls (N = 37). Compared to controls, the NAcc-MPFC circuit’s connectivity was significantly reduced in fibromyalgia. In addition, within the fibromyalgia group, NAcc-MPFC connectivity was significantly correlated with trait anxiety. Our expanded connectivity analysis of the NAcc to subcortical brain regions showed reduced connectivity of the right NAcc with mesolimbic circuit regions (putamen, thalamus, and ventral pallidum) in fibromyalgia. Lastly, in an exploratory analysis comparing our fibromyalgia and healthy control cohorts to a separate publicly available dataset from patients with chronic back pain, we identified reduced NAcc-MPFC connectivity across both the patient groups with unique alterations in NAcc-mesolimbic connectivity. Together, expanding upon prior observed alterations in brain corticostriatal circuits, our results provide novel evidence of altered corticostriatal and mesolimbic circuits in chronic pain.
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影响因子：
16.2
作者：
Baliki, Marwan N.;Geha, Paul Y.;Fields, Howard L.;Apkarian, A. Vania
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