Reverse translated and gold standard continuous performance tests predict global cognitive performance in schizophrenia.
Reverse translated and gold standard continuous performance tests predict global cognitive performance in schizophrenia.
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DOI：
10.1038/s41398-018-0127-5
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发表时间：
2018-04-12
影响因子：
6.8
通讯作者：
Light GA
中科院分区：
文献类型：
--
作者：
Bismark AW;Thomas ML;Tarasenko M;Shiluk AL;Rackelmann SY;Young JW;Light GA
注意力功能障碍会导致精神分裂症（SZ）的功能障碍。持续注意力通常是通过持续表现任务（CPT）来评估的，尽管许多 CPT 的跨物种转化有效性有限并且对额外的认知领域提出了要求。用于人体测试的反向翻译 5 选择连续性能任务 (5C-CPT) 最初是为啮齿类动物开发的，旨在最大限度地减少对感知、视觉学习、处理速度或工作记忆功能的要求。迄今为止，还没有研究根据金标准注意力测量来验证 5C-CPT，也没有评估 5C-CPT 分数与 SZ 认知的关系。在这里，我们检查了 5C-CPT 和 CPT-Identical Pairs (CPT-IP) 之间的关系，这是一种在 SZ 患者样本 (n = 35) 中通过 MATRICS 共识认知电池 (MCCB) 建立的、心理测量上稳健的警惕性测量方法。还评估了与全局和个体认知子域的关系。 5C-CPT 和 CPT-IP 性能测量（d-prime）密切相关（r = 0.60）。在回归模型中，5C-CPT 和 CPT-IP 共同占 MCCB 总分总方差的 54%，5C-CPT 和 CPT-IP 共同占总体认知方差的 27.6%。这些结果表明，反向翻译的 5C-CPT 和黄金标准 CPT-IP 指数是一种常见的注意力结构，也与一般认知表现的方差显着重叠。使用简单的、跨物种验证的注意力/认知功能行为指数（例如 5C-CPT）可以加速针对 SZ 和相关神经精神疾病的新型通用促认知疗法的开发。
Attentional dysfunction contributes to functional impairments in schizophrenia (SZ). Sustained attention is typically assessed via continuous performance tasks (CPTs), though many CPTs have limited cross-species translational validity and place demands on additional cognitive domains. A reverse-translated 5-Choice Continuous Performance Task (5C-CPT) for human testing—originally developed for use in rodents—was designed to minimize demands on perceptual, visual learning, processing speed, or working memory functions. To-date, no studies have validated the 5C-CPT against gold standard attentional measures nor evaluated how 5C-CPT scores relate to cognition in SZ. Here we examined the relationship between the 5C-CPT and the CPT-Identical Pairs (CPT-IP), an established and psychometrically robust measure of vigilance from the MATRICS Consensus Cognitive Battery (MCCB) in a sample of SZ patients (n = 35). Relationships to global and individual subdomains of cognition were also assessed. 5C-CPT and CPT-IP measures of performance (d-prime) were strongly correlated (r = 0.60). In a regression model, the 5C-CPT and CPT-IP collectively accounted for 54% of the total variance in MCCB total scores, and 27.6% of overall cognitive variance was shared between the 5C-CPT and CPT-IP. These results indicate that the reverse translated 5C-CPT and the gold standard CPT-IP index a common attentional construct that also significantly overlaps with variance in general cognitive performance. The use of simple, cross-species validated behavioral indices of attentional/cognitive functioning such as the 5C-CPT could accelerate the development of novel generalized pro-cognitive therapeutics for SZ and related neuropsychiatric disorders.
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影响因子：
4.5
作者：
Bismark AW;Thomas ML;Tarasenko M;Shiluk AL;Rackelmann SY;Young JW;Light GA
通讯作者：
Light GA
影响因子：
11.3
作者：
Lee, Kwang-Hyuk;Tsoi, Daniel T.;Woodruff, Peter W. R.
通讯作者：
Woodruff, Peter W. R.
DOI：
10.1111/gbb.12268
发表时间：
2016-01
期刊：
Genes, brain, and behavior
影响因子：
--
作者：
Cope ZA;Powell SB;Young JW
通讯作者：
Young JW
DOI：
10.1176/appi.ajp.2017.16040400
发表时间：
2017-07-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
McTeague LM;Huemer J;Carreon DM;Jiang Y;Eickhoff SB;Etkin A
通讯作者：
Etkin A
影响因子：
3.4
作者：
Barnes SA;Young JW;Neill JC
通讯作者：
Neill JC