Synchronizing neural rhythms.

Synchronizing neural rhythms.
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DOI:
10.1126/science.add4834
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发表时间:
2022-08-05
期刊:
Science (New York, N.Y.)
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其他
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认知脑障碍是世界上最具致残性的健康状态之一。现有的认知障碍的药物,手术和行为治疗方法受到异质性治疗结果,症状缓解缓慢以及伴随的风险和副作用的限制。因此,迫切需要开发创新和个性化的治疗干预措施,能够提供快速和可持续的改善,副作用最小。非侵入性神经调节技术是一类新兴的工具,为神经认知障碍提供了这种转化潜力。高清晰度经颅交流电刺激(HD-tACS)等工具在调节与神经认知功能障碍有关的皮质区域的节律活动方面提供了前所未有的控制。我们在精确或个性化HD-tACS方面的最新研究显示,在非侵入性地操纵神经群体动态以及以选择性和持久的方式改善人类认知和适应行为方面有希望。
Cognitive brain disorders are among the most disabling health states in the world. Existing pharmacological, surgical, and behavioral therapeutic approaches for impaired cognition are limited by heterogeneous treatment outcomes, slow symptom resolution, and accompanying risks and side effects. Consequently, there is an urgent need to develop innovative and personalized therapeutic interventions that are capable of providing rapid and sustainable improvements with minimal side effects. Noninvasive neuromodulation technology is an emerging class of tools that offer such translational potential for neurocognitive disorders. Tools such as high-definition transcranial alternating current stimulation (HD-tACS) offer unprecedented control in modulating rhythmic activity in cortical regions that are implicated in neurocognitive dysfunction . Our latest research in precision or personalized HD-tACS shows promise at noninvasively manipulating neural population dynamics and improving human cognition and adaptive behavior in a selective and long-lasting fashion (–).
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