A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry.
A comparison of the demographics, clinical features, and survival of patients with adenoid cystic carcinoma of major and minor salivary glands versus less common sites within the Surveillance, Epidemiology, and End Results registry.
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DOI：
10.1002/cncr.26740
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发表时间：
2012-08-15
期刊：
影响因子：
6.2
通讯作者：
Sturgis EM
中科院分区：
文献类型：
--
作者：
Li N;Xu L;Zhao H;El-Naggar AK;Sturgis EM
迄今为止，科学文献缺乏基于人群的研究，人口统计学，临床特征和不同解剖部位的腺样囊性癌（ACC）患者的生存率。我们从监测、流行病学和最终结果（SEER）登记处确定了5349例ACC病例，包括大唾液腺（N=1850）、小唾液腺（N=2077）、乳腺（N=696）、皮肤（N=291）、肺和支气管（N=203）、女性生殖系统（N=132）以及眼和眼眶（N=100）。评估了患者的人口统计学、临床特征和生存率的差异。眼睛和眼眶的ACC与就诊时的年轻年龄相关（平均=49.9岁）。皮肤或乳房的ACC倾向于表现出较不积极的预后特征，而肺和支气管或眼睛和眼眶的ACC倾向于表现出更积极的预后特征。多因素生存分析结果显示，乳腺ACC（HR=0.40）或皮肤ACC（HR=0.40）的死亡风险显著低于大涎腺ACC，而肺和支气管ACC（HR=3.72）或眼和眼眶ACC（HR=3.67）的死亡风险显著高于大涎腺ACC。对于表现为局部病变的患者，多变量分析中唯一明确的预后差异是皮肤ACC患者的预后明显更好。ACC的人口统计学和临床特征因疾病部位而异。部位可能是局部疾病患者生存的重要预测因素，但对局部疾病患者不太重要。
The scientific literature to date lacks population-based studies on the demographics, clinical features, and survival of patients with adenoid cystic carcinoma (ACC) of different anatomic sites. We identified 5349 ACC cases in major salivary glands (N=1850), minor salivary glands (N=2077), breast (N=696), skin (N=291), lung and bronchus (N=203), female genital system (N=132), and eye and orbit (N=100) from the Surveillance, Epidemiology, and End Results (SEER) registry. Differences in demographics, clinical features, and survival of patients were assessed. ACC of the eye and orbit was associated with younger age at presentation (mean=49.9 years). ACC of the skin or breast tended to present with less aggressive prognostic features, while ACC of the lung and bronchus or eye and orbit tended to present with more aggressive prognostic features. In multivariate survival analysis of patients presenting with localized disease, patients with ACC of breast (HR=0.40) or skin (HR=0.40) had a significantly lower risk death than patients with ACC of major salivary glands, while patients with ACC of lung and bronchus (HR=3.72) or eye and orbit (HR=3.67) had a significantly higher risk. For patients presenting with regional disease, the only clear prognostic difference in multivariate analysis was that patients with ACC of skin did significantly better. The demographics and clinical features of ACC differ by disease site. Site may be an important predictor of survival for patients presenting with localized disease but is less important for patients presenting with regional disease.
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DOI：
10.1186/bcr2613
发表时间：
2010
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Ghabach B;Anderson WF;Curtis RE;Huycke MM;Lavigne JA;Dores GM
通讯作者：
Dores GM
影响因子：
4.8
作者：
Bjorndal, Kristine;Krogdahl, Annelise;Godballe, Christian
通讯作者：
Godballe, Christian
影响因子：
4.8
作者：
Ciccolallo, Laura;Licitra, Lisa;Gatta, Gemma
通讯作者：
Gatta, Gemma
影响因子：
6.2
作者：
Molina, Julian R.;Aubry, Marie Christine;Cassivi, Stephen D.
通讯作者：
Cassivi, Stephen D.
影响因子：
0.8
作者：
LORENZ, B;STEFANI, FH;THEOPOLD, M
通讯作者：
THEOPOLD, M