The effects of amphetamine sensitization on conditioned inhibition during a Pavlovian-instrumental transfer task in rats.
The effects of amphetamine sensitization on conditioned inhibition during a Pavlovian-instrumental transfer task in rats.
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DOI：
10.1007/s00213-013-3144-3
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发表时间：
2013-11
影响因子：
3.4
通讯作者：
DiMatteo, RoseMarie
中科院分区：
文献类型：
--
作者：
Shiflett, Michael W.;Riccie, Meaghan;DiMatteo, RoseMarie
心理刺激敏感化增强了对奖赏相关刺激的行为和动机反应；然而，它对与奖赏缺失相关的刺激的影响却鲜为人知。我们研究了苯丙胺敏化是否改变了巴甫洛夫-仪器转移术(PIT)中对条件性兴奋药和抑制药的反应。我们进一步试图通过在巴甫洛夫训练之前或在训练和测试之间让大鼠暴露于苯丙胺来表征苯丙胺敏化对学习和表现的影响。成年雄性Long Evans大鼠给予条件性抑制(A+/AX−)和巴甫洛夫(B+)训练，然后进行变间隔工具性条件反射训练。D-苯丙胺致敏大鼠(每日注射2 mg/kg，连续7天)，或作为非暴露对照组。对大鼠进行坑试验，给予单独刺激B或与条件抑制物(BX)复合刺激。在PIT测试中，对照组大鼠在BX试验中显著降低了仪器反应(约为B反应的50%)。与对照组相比，巴甫洛夫条件作用前的苯丙胺敏化增加了BX试验的杠杆压力，减少了B试验的杠杆压力。与对照组相比，训练和测试之间的苯丙胺敏化增加了B和BX试验的杠杆压力。条件性食物杯法未观察到致敏作用。苯丙胺的敏化通过增强条件性刺激的兴奋和减少条件性抑制物的抑制来增加PIT过程中对条件抑制的仪器反应。
Psychostimulant sensitization heightens behavioral and motivational responses to reward-associated stimuli; however, its effects on stimuli associated with reward absence are less understood. We examined whether amphetamine sensitization alters performance during Pavlovian-instrumental transfer (PIT) to conditioned excitors and inhibitors. We further sought to characterize the effects of amphetamine sensitization on learning versus performance by exposing rats to amphetamine prior to Pavlovian training or between training and test. Adult male Long Evans rats were given conditioned inhibition (A+/AX−) and Pavlovian (B+) training, followed by variable-interval instrumental conditioning. Rats were sensitized to d-amphetamine (2 mg/kg daily injections for seven days), or served as non-exposed controls. Rats were given a PIT test, in which they were presented with stimulus B alone or in compound with the conditioned inhibitor (BX). During the PIT test, control rats significantly reduced instrumental responding on BX trials (to approximately 50% of responding to B). Amphetamine sensitization prior to Pavlovian conditioning increased lever-pressing on BX trials and reduced lever-pressing on B trials compared to controls. Amphetamine sensitization between training and test increased lever-pressing on B and BX trials compared to controls. No effects of sensitization were observed on conditioned food-cup approach. Amphetamine sensitization increases instrumental responding during PIT to a conditioned inhibitor, by enhancing excitation of conditioned stimuli and reducing inhibition of conditioned inhibitors.
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影响因子：
64.8
作者：
Flagel SB;Clark JJ;Robinson TE;Mayo L;Czuj A;Willuhn I;Akers CA;Clinton SM;Phillips PE;Akil H
通讯作者：
Akil H
影响因子：
5.3
作者：
Bray, Signe;Rangel, Antonio;O'Doherty, John P.
通讯作者：
O'Doherty, John P.
影响因子：
3.4
作者：
EHRMAN, RN;ROBBINS, SJ;OBRIEN, CP
通讯作者：
OBRIEN, CP
影响因子：
1.9
作者：
Dickinson, A;Smith, J;Mirenowicz, J
通讯作者：
Mirenowicz, J
DOI：
10.1037/0097-7403.34.2.202
发表时间：
2008-04-01
期刊：
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL BEHAVIORAL PROCESSES
影响因子：
--
作者：
Delamater, Andrew R.;Holland, Peter C.
通讯作者：
Holland, Peter C.