Proarrhythmic risk and determinants of cardiac autonomic dysfunction in collagen-induced arthritis rats.
Proarrhythmic risk and determinants of cardiac autonomic dysfunction in collagen-induced arthritis rats.
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胶原诱导的关节炎大鼠的致心律失常风险和心脏自主神经功能障碍的决定因素
DOI：
10.1186/s12891-016-1347-6
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发表时间：
2016-11-29
影响因子：
2.3
通讯作者：
Lin SF
中科院分区：
文献类型：
--
作者：
Lin TT;Sung YL;Wu CE;Zhang H;Liu YB;Lin SF
类风湿性关节炎(RA)患者发生心脏性猝死(SCD)的风险增加，是普通人群的两倍。SCD的驱动原因被认为是由于威胁抬高的心律失常，其中全身炎症是将RA与自主功能障碍联系起来的病理生理学基础。为了评估“炎症反射”的交感过度活动，我们测量了大鼠胶原诱导性关节炎(CIA)模型的心率变异性(HRV)，该模型是通过皮内注射II型胶原乳剂诱导的。每两天记录一次单导联心电图(ECG)，每次30min。分析了时域和频域参数、去趋势波动分析(DFA)、减速(DC)和加速能力(AC)。与9只对照大鼠相比，9只CIA大鼠的多项心率变异性参数均有显著差异。在关节炎开始时，LF/HF显著高于对照组(第1周：2.41 ± 0.7vs.1.76 ± 0.6，p <； 0.05；第2周：2.24 ± 0.5vs.1.58 ± 0.5，p <； 0.05)，表明炎症反应在炎症初期强烈，但在随后的恢复期无显著差异。注意到DFA参数的类似趋势。但从第4周开始，尽管LF/HF与对照组相比无明显升高，DC仍呈进行性下降。我们观察到在CIA大鼠关节炎早期交感神经过度激活的炎症反射。无论急性关节炎缓解与否，DC持续下降表明心脏自主神经功能紊乱。本文的在线版本(doi：10.1186/s12891-0161347-6)包含补充材料，授权用户可以使用。
Patients with rheumatoid arthritis (RA) have increased risk of sudden cardiac death (SCD), which is two-fold higher than general population. The driving cause of SCD was considered due to lift-threatening arrhythmia where systemic inflammation acts as the pathophysiological basis linking RA to autonomicdysfunction. To assess the sympathetic over-activity of “inflammatory reflex”, we measured heart rate variability (HRV) in a rat collagen-induced arthritis (CIA) model, whose arthritis is induced in Lewis rats by intradermal injection of emulsion of type II collagen. Single-lead electrocardiogram (ECG) was recorded for 30 min every two days. Time and frequency-domain parameters, detrended fluctuation analysis (DFA), deceleration (DC) and acceleration capacity (AC) were analyzed. Compared with 9 control rats, many of HRV parameters of 9 CIA rats revealed significant different. At the beginning of arthritis, LF/HF was significant higher than controls (1st week: 2.41 ± 0.7 vs. 1.76 ± 0.6, p < 0.05; 2nd week: 2.24 ± 0.5 vs. 1.58 ± 0.5, p < 0.05) indicating intensive inflammatory reflex at the initial phase of inflammation but no significant difference was observed in the following recover phase. The similar trend of DFA parameters was noted. However, the DC appeared progressive lower despite of no significant increase of the LF/HF compared with controls since 4th week. We observed sympathetic over-activation of inflammatory reflex during early stage of arthritis in CIA rats. The ongoing decline of DC indicated advanced cardiac autonomic dysfunction regardless of remission of acute arthritis. The online version of this article (doi:10.1186/s12891-016-1347-6) contains supplementary material, which is available to authorized users.
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影响因子：
13.6
作者：
Stojanovich, Ljudmila
通讯作者：
Stojanovich, Ljudmila
DOI：
10.1007/978-1-60761-058-8_11
发表时间：
2010-01-01
期刊：
MOUSE MODELS FOR DRUG DISCOVERY: METHODS AND PROTOCOLS
影响因子：
--
作者：
Bevaart, Lisette;Vervoordeldonk, Margriet J.;Tak, Paul P.
通讯作者：
Tak, Paul P.
影响因子：
168.9
作者：
Bauer, Axel;Kantelhardt, Jan W.;Schmidt, Georg
通讯作者：
Schmidt, Georg
影响因子：
2.6
作者：
Aydemir, M.;Yazisiz, V.;Terzioglu, E.
通讯作者：
Terzioglu, E.
影响因子：
10.8
作者：
LI, YH;ROZANSKI, GJ
通讯作者：
ROZANSKI, GJ