Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased.
Gut Microbiota Characterization in Patients with Asymptomatic Hyperuricemia: probiotics increased.
复制标题
无症状高尿酸血症患者肠道菌群特征：益生菌增加
DOI：
10.1080/21655979.2021.1976897
复制
发表时间：
2021-12
期刊：
影响因子：
4.9
通讯作者：
Xie X
中科院分区：
文献类型：
--
作者：
Yang HT;Xiu WJ;Liu JK;Yang Y;Hou XG;Zheng YY;Wu TT;Wu CX;Xie X
摘要无症状性高尿酸血症(AH)是痛风的早期症状。越来越多的证据表明，肠道微生物区系与痛风有关。然而，AH与肠道微生物区系之间的关系却知之甚少。因此，本研究的目的是探讨AH与肠道菌群之间的可能相关性。通过16S rRNA基因测序和聚类分析，比较了45例AH患者和45例健康人的肠道微生物群落。肠型聚集型可分为两组，不同肠型之间AH型的比例有显著差异。AH组的α多样性指数高于对照组，β多样性指数也有显著差异。AH组与对照组共发现19个不同属。与对照组相比，一些益生菌在AH群体中有所增加。根据细菌的重要性对两组进行了排名。发现不同细菌与重要细菌部分重合，重要细菌联合诊断水平较好。结论：急性胰腺炎患者肠道菌群组成与健康人有显著差异。部分益生菌在急性期有所增加。
ABSTRACT Asymptomatic hyperuricemia (AH) is an early stage of gout. Emerging evidence shows that the intestinal microbiota is related to gout. However, the relationship between AH and the intestinal microbiota is poorly understood. Therefore, the aim of the current study was to explore the possible correlation between AH and intestinal flora. We compared the intestinal microbial communities of AH (45 cases) and healthy subjects (45 cases) by 16S rRNA gene sequencing and clustering analysis on the incorporated population. Intestinal-type clustering can be divided into two groups, and significant differences in the proportion of AH are found among different bowel types. Alpha diversity indices were higher in the AH group than in the control group, and beta diversity indices also showed significant differences. A total of 19 genera were found different between the AH group and the control group. Compared with the control group, some probiotics are increased in the AH population. Two groups were ranked by importance of bacteria. We found the different bacteria partially coincided with the important bacteria, and the joint diagnosis level of the important bacteria was good. Conclusion: There were significant differences in the composition of intestinal biota between AH patients and healthy subjects. Some probiotics increased in AH.
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DOI：
10.1186/s10020-021-00311-5
发表时间：
2021-05-24
期刊：
Molecular medicine (Cambridge, Mass.)
影响因子：
--
作者：
Méndez-Salazar EO;Vázquez-Mellado J;Casimiro-Soriguer CS;Dopazo J;Çubuk C;Zamudio-Cuevas Y;Francisco-Balderas A;Martínez-Flores K;Fernández-Torres J;Lozada-Pérez C;Pineda C;Sánchez-González A;Silveira LH;Burguete-García AI;Orbe-Orihuela C;Lagunas-Martínez A;Vazquez-Gomez A;López-Reyes A;Palacios-González B;Martínez-Nava GA
通讯作者：
Martínez-Nava GA
影响因子：
5.7
作者：
Balaguer F;Enrique M;Llopis S;Barrena M;Navarro V;Álvarez B;Chenoll E;Ramón D;Tortajada M;Martorell P
通讯作者：
Martorell P
影响因子：
4.6
作者：
Guo Z;Zhang J;Wang Z;Ang KY;Huang S;Hou Q;Su X;Qiao J;Zheng Y;Wang L;Koh E;Danliang H;Xu J;Lee YK;Zhang H
通讯作者：
Zhang H
玉米赤霉烯酮改变断奶兔盲肠微生物群的多样性和组成
影响因子：
--
作者：
Li P;Yang S;Zhang X;Huang S;Wang N;Wang M;Long M;He J
通讯作者：
He J
肾功能正常的 2 型糖尿病患者的高尿葡萄糖排泄率降低了血清尿酸水平
影响因子：
5.4
作者：
Qin Y;Zhang S;Cui S;Shen X;Wang J;Cui X;Zuo M;Gao Z;Zhang J;Yang J;Zhu H;Chang B
通讯作者：
Chang B