Adipose-derived mesenchymal stem cells accelerate nerve regeneration and functional recovery in a rat model of recurrent laryngeal nerve injury.
Adipose-derived mesenchymal stem cells accelerate nerve regeneration and functional recovery in a rat model of recurrent laryngeal nerve injury.
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脂肪间充质干细胞加速喉返神经损伤大鼠模型的神经再生和功能恢复
DOI：
10.4103/1673-5374.215267
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发表时间：
2017-09
影响因子：
6.1
通讯作者：
Cheng LY
中科院分区：
文献类型：
--
作者：
Li Y;Xu W;Cheng LY
单侧声带麻痹行内侧化甲状腺成形术或注射喉成形术均不能恢复声带的活动度。近年来的研究表明，骨髓间充质干细胞移植对神经损伤的修复是有效的。本研究旨在探讨脂肪干细胞移植能否修复喉返神经损伤。采用显微钳夹法建立大鼠喉返神经损伤模型。在损伤部位注射脂肪来源的间充质干细胞（ADSCs; 8 × 105）或分化的Schwann样脂肪来源的间充质干细胞（dADSCs; 8 × 105）或细胞外基质。术后2、4、6周，与细胞外基质组相比，ADSCs和dADSCs组有髓神经纤维密度更高，髓鞘更厚，声带运动改善，神经传导能力恢复更好，甲杓肌萎缩减少。在ADSC组中的效果比在dADSC组中更明显。这些实验结果表明，ADSCs移植可能是促进喉返神经损伤后再生的早期干预策略。
Medialization thyroplasty or injection laryngoplasty for unilateral vocal fold paralysis cannot restore mobility of the vocal fold. Recent studies have shown that transplantation of mesenchymal stem cells is effective in the repair of nerve injuries. This study investigated whether adipose-derived stem cell transplantation could repair recurrent laryngeal nerve injury. Rat models of recurrent laryngeal nerve injury were established by crushing with micro forceps. Adipose-derived mesenchymal stem cells (ADSCs; 8 × 105) or differentiated Schwann-like adipose-derived mesenchymal stem cells (dADSCs; 8 × 105) or extracellular matrix were injected at the site of injury. At 2, 4 and 6 weeks post-surgery, a higher density of myelinated nerve fiber, thicker myelin sheath, improved vocal fold movement, better recovery of nerve conduction capacity and reduced thyroarytenoid muscle atrophy were found in ADSCs and dADSCs groups compared with the extracellular matrix group. The effects were more pronounced in the ADSCs group than in the dADSCs group. These experimental results indicated that ADSCs transplantation could be an early interventional strategy to promote regeneration after recurrent laryngeal nerve injury.
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影响因子：
2.7
作者：
Mantovani, Cristina;Mahay, Daljeet;Wiberg, Mikael
通讯作者：
Wiberg, Mikael
影响因子：
--
作者：
Keilhoff, Gerburg;Goihl, Alexander;Fansa, Hisham
通讯作者：
Fansa, Hisham
影响因子：
6.1
作者：
Torii T;Yamauchi J
通讯作者：
Yamauchi J
DOI：
10.1016/j.bjps.2010.08.013
发表时间：
2010-12-01
影响因子：
2.7
作者：
Erba, P.;Mantovani, C.;Kingham, P. J.
通讯作者：
Kingham, P. J.
影响因子：
3.3
作者：
di Summa, P. G.;Kalbermatten, D. F.;Terenghi, G.
通讯作者：
Terenghi, G.