Systematic literature review of role of noroviruses in sporadic gastroenteritis.
Systematic literature review of role of noroviruses in sporadic gastroenteritis.
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DOI：
10.3201/eid1408.071114
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发表时间：
2008-08
影响因子：
11.8
通讯作者：
Parashar, Umesh D.
中科院分区：
文献类型：
--
作者：
Patel, Manish M.;Widdowson, Marc-Alain;Glass, Roger I.;Akazawa, Kenichiro;Vinje, Jan;Parashar, Umesh D.
诺如病毒占5岁以下儿童严重胃肠炎病例的12%。我们对使用逆转录-PCR诊断轻度或中度（门诊）和重度（住院）腹泻患者诺如病毒（NoV）感染的研究进行了系统回顾。NoV占5岁以下儿童重度胃肠炎病例的12%（95%置信区间[CI] 10%-15%），占所有年龄段人群轻度和中度腹泻病例的12%（95% CI 9%-15%）。在19项针对5岁以下儿童的研究中，7项在发展中国家进行，这些国家的重度NoV疾病合并患病率（12%）与工业化国家（12%）相当。我们估计，在工业化国家，每年NoV导致64，000例腹泻，需要住院治疗，900，000例儿童就诊，在发展中国家，多达200，000例5岁以下儿童死亡。未来的努力应该集中在制定有针对性的战略，甚至可能是疫苗，以预防新型冠状病毒疾病，并更好地记录其对发展中国家儿童的影响，因为95%以上的腹泻死亡发生在发展中国家。
Noroviruses accounted for 12% of severe gastroenteritis cases among children <5 years of age. We conducted a systematic review of studies that used reverse transcription–PCR to diagnose norovirus (NoV) infections in patients with mild or moderate (outpatient) and severe (hospitalized) diarrhea. NoVs accounted for 12% (95% confidence interval [CI] 10%–15%) of severe gastroenteritis cases among children <5 years of age and 12% (95% CI 9%–15%) of mild and moderate diarrhea cases among persons of all ages. Of 19 studies among children <5 years of age, 7 were in developing countries where pooled prevalence of severe NoV disease (12%) was comparable to that for industrialized countries (12%). We estimate that each year NoVs cause 64,000 episodes of diarrhea requiring hospitalization and 900,000 clinic visits among children in industrialized countries, and up to 200,000 deaths of children <5 years of age in developing countries. Future efforts should focus on developing targeted strategies, possibly even vaccines, for preventing NoV disease and better documenting their impact among children living in developing countries, where >95% of the deaths from diarrhea occur.
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影响因子：
12.7
作者：
通讯作者：
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影响因子：
5
作者：
de Wit, MAS;Koopmans, MPG;van Duynhoven, YTHF
通讯作者：
van Duynhoven, YTHF
影响因子：
6.4
作者：
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通讯作者：
Monroe, SS
影响因子：
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通讯作者：
Titone, Lucina
影响因子：
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作者：
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