Porous Polylactide Film Plus Atorvastatin-Loaded Thermogel as an Efficient Device for Peritoneal Adhesion Prevention.
Porous Polylactide Film Plus Atorvastatin-Loaded Thermogel as an Efficient Device for Peritoneal Adhesion Prevention.
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多孔聚丙交酯薄膜加阿托伐他汀热凝胶作为预防腹膜粘连的有效装置
DOI：
10.1021/acsomega.8b00090
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发表时间：
2018-03-31
期刊：
影响因子：
4.1
通讯作者：
Ding J
中科院分区：
文献类型：
--
作者：
Li J;Feng X;Shi J;Liu T;Ding J
腹膜粘连是一种常见的术后并发症，可引起多种器官功能障碍。通过物理隔离和药物治疗相结合，可以将其降至最低。然而，传统防粘连医疗器械的透气性不理想，增加了感染和炎症的风险，从而促进了腹膜粘连的形成。在这项研究中，多孔聚乳酸（PLA）膜加阿托伐他汀（ATV）负载的热凝胶的装置被开发用于预防腹膜粘连。聚乳酸膜作为一种物理屏障，防止损伤组织与邻近正常器官之间的纤维蛋白桥连接。同时释放ATV，达到抗纤维蛋白沉积和抗炎作用。PLA膜和热凝胶的多孔性增加了气体渗透性，并进一步抑制了炎症反应。体内实验表明，载ATV热凝胶的PLA多孔膜具有良好的抗炎和抗粘连能力，具有良好的临床应用前景。
Peritoneal adhesion is a common postoperative complication that causes many kinds of organ dysfunctions. It can be minimized by the integration of physical isolation and pharmaceutical treatment. However, the gas permeability of traditional medical devices for adhesion prevention is not satisfactory, which increases the risk of infection and inflammation, thus facilitating the formation of peritoneal adhesion. In this study, a device of porous polylactide (PLA) film plus atorvastatin (ATV)-loaded thermogel was developed for peritoneal adhesion prevention. PLA film acted as a physical barrier to prevent the connection of fibrin bridges between the injured tissues and nearby normal organs. Simultaneously, ATV was released to achieve the antifibrin deposition and anti-inflammatory effect. The porous properties of PLA film and thermogel increased the gas permeability and further inhibited the inflammatory responses. The in vivo study demonstrated that the porous PLA film with ATV-loaded thermogel possessed excellent anti-inflammation ability and satisfactory antiadhesion capacity, indicating its great potential for clinical application.
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