Tissue repair and regeneration with endogenous stem cells
Tissue repair and regeneration with endogenous stem cells
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内源性干细胞的组织修复和再生
DOI：
10.1038/s41578-018-0027-6
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发表时间：
2018-06
影响因子：
83.5
通讯作者：
Zhang Kang
中科院分区：
文献类型：
--
作者：
Xia Huimin;Li Xin;Gao Weiwei;Fu Xin;Fang Ronnie H;Zhang Liangfang;Zhang Kang
与非哺乳动物脊椎动物相比，由于遗传、发育、免疫系统和组织复杂性的差异，哺乳动物和人类的组织和器官自我再生的先天能力有限。内源干细胞是组织特异性成体干细胞，具有自我更新和分化成特定细胞类型的能力。因此，人们正在探索内源干细胞用于原位和体内组织的再生。干细胞驻留在体内的特定生态位中，干细胞的激活取决于生态位的逐渐变化。生态位是特定的、有指导性的微环境，可以使用基于生物材料的支架来重建。这种支架可以制成各种形状和配方，并且可以利用生化和生物物理线索进行功能化，以指导干细胞的命运和迁移。在这篇综述中，我们讨论了非哺乳动物脊椎动物和哺乳动物（包括人类）自我再生能力的重要差异，并研究了成体干细胞群及其参与组织修复和再生的生态位。我们重点介绍天然和合成生物材料及其改善内源干细胞应用的潜力，并研究种间嵌合体在再生医学中的作用。
In contrast to non-mammalian vertebrates, mammals and humans have limited innate capacity for the self-regeneration of tissues and organs owing to differences in genetics, development, immune systems and tissue complexity. Endogenous stem cells are tissue-specific adult stem cells with the capacity to self-renew and differentiate into specific cell types. Therefore, endogenous stem cells are being explored for the regeneration of tissues in situ and in vivo. Stem cells reside in specific niches in the body, and stem cell activation depends on progressive changes in the niche. Niches are specific and instructive microenvironments that can be recreated using biomaterial-based scaffolds. Such scaffolds can be fabricated into a variety of shapes and formulations, and they can be functionalized with biochemical and biophysical cues to guide stem cell fate and migration. In this Review, we discuss important differences in the self-regeneration abilities of non-mammalian vertebrates and mammals, including humans, and investigate adult stem cell populations and their niches involved in tissue repair and regeneration. We highlight natural and synthetic biomaterials and their potential for improving applications of endogenous stem cells and examine the role of interspecies chimaeras in regenerative medicine.
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影响因子：
11.8
作者：
Tornini, Valerie A.;Poss, Kenneth D.
通讯作者：
Poss, Kenneth D.
影响因子：
--
作者：
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通讯作者：
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影响因子：
8
作者：
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通讯作者：
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影响因子：
16.6
作者：
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通讯作者：
Cho DW
DOI：
10.1016/j.jtcvs.2011.10.005
发表时间：
2012-01-01
影响因子：
6
作者：
Jordan, James E.;Williams, J. Koudy;Yoo, James J.
通讯作者：
Yoo, James J.