Tick⁻Virus⁻Host Interactions at the Cutaneous Interface: The Nidus of Flavivirus Transmission.

Tick⁻Virus⁻Host Interactions at the Cutaneous Interface: The Nidus of Flavivirus Transmission.
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DOI:
10.3390/v10070362
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发表时间:
2018-07-07
期刊:
Viruses
影响因子:
--
通讯作者:
Thangamani S
Thangamani S
中科院分区:
其他
文献类型:
--
作者:
Hermance ME;Thangamani S

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蜱虫传播的病毒性疾病继续在美国出现,波瓦桑脑炎病毒、哈特兰病毒和波旁病毒感染的增加清楚地表明了这一点。蜱传黄病毒(TBFV)在吸血期间随受感染的蜱唾液沿着传播给哺乳动物宿主。成功的蜱进食是由蜱唾液中的一系列复杂的唾液活性蛋白/因子促进的。这些唾液因子在宿主皮肤中创造了免疫特权微环境,影响病毒传播和发病机制。在这篇综述中,我们将突出蜱TBFV传播的决定因素,特别强调在皮肤界面的蜱-病毒-宿主的相互作用。
Tick-borne viral diseases continue to emerge in the United States, as clearly evident from the increase in Powassan encephalitis virus, Heartland virus, and Bourbon virus infections. Tick-borne flaviviruses (TBFVs) are transmitted to the mammalian host along with the infected tick saliva during blood-feeding. Successful tick feeding is facilitated by a complex repertoire of pharmacologically active salivary proteins/factors in tick saliva. These salivary factors create an immunologically privileged micro-environment in the host’s skin that influences virus transmission and pathogenesis. In this review, we will highlight tick determinants of TBFV transmission with a special emphasis on tick–virus–host interactions at the cutaneous interface.
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