Damp indicators in different areas of residence in different periods are strongly associated with childhood asthma and wheeze
Damp indicators in different areas of residence in different periods are strongly associated with childhood asthma and wheeze
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不同时期不同居住地区的潮湿指标与儿童哮喘、喘息密切相关
DOI：
10.1016/j.buildenv.2020.107131
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发表时间：
2020-09
影响因子：
7.4
通讯作者：
Wang Yujue
中科院分区：
文献类型：
--
作者：
Cai Jiao;Li Baizhan;Yu Wei;Wang Lexiang;Yao Yinghui;Wang Yujue
2019年6月，我们在中国重庆对4534名3 - 7岁的学龄前儿童开展了一项横断面研究。在此，我们针对选定的2563名从未搬过家的学龄前儿童，探究了家庭潮湿暴露与儿童过敏及气道疾病之间的关联。与无潮湿暴露的儿童相比，在任何时期（怀孕前一年、孕期、出生后第一年、调查前一年），家中任何区域（客厅、卧室和浴室）出现五种潮湿迹象（水损、窗玻璃结露、发霉气味、可见霉斑、可见湿渍）中任意一种的儿童，其哮喘、过敏性鼻炎、肺炎、湿疹、喘息和鼻炎的患病率显著更高。在两级（地区 - 儿童）逻辑回归分析中，多数情况下，不同时期不同区域的五种潮湿迹象与所研究疾病的发病几率增加显著相关。潮湿迹象累积得分、出现潮湿迹象的区域得分以及有潮湿暴露的时期得分，与所研究疾病存在数量 - 反应关系，尤其是哮喘、终身曾患喘息、过敏性鼻炎以及当前喘息。这些关联和数量 - 反应关系，对于客厅和卧室中的可见霉斑和可见湿渍而言，比其他潮湿迹象更为显著；对于孕期和出生后第一年而言，比怀孕前一年和调查前一年更为显著。我们的研究结果为室内潮湿暴露对儿童哮喘和喘息的影响提供了有力证据，且似乎表明了它们之间潜在的因果关系。
During June 2019, we conducted a cross-sectional study among 4534 preschoolers 3-7 years old in Chongqing, China. Here, we investigated associations of home dampness exposures with childhood allergies and airway diseases among the selected 2563 preschoolers who never changed residence. Compared to children without dampness exposures, children exposed to any of five damp indicators (water damage, condensation on windowpane, moldy odor, visible mold spots, visible damp stains) in any areas (living room, bedroom, and bathroom) during any periods (one year before pregnancy, during pregnancy, first year of lifetime, in the past year before the survey) had significantly higher prevalences of asthma, allergic rhinitis, pneumonia, eczema, wheeze, and rhinitis. In the two-level (district-child) logistic regression analyses, five damp indicators in the different areas during different periods were significantly associated with the increased odds of the studied diseases in most cases. The cumulative scores of damp indicators, scores of areas with damp indicators, and scores of periods with dampness exposures had number-response relationships with the studied diseases, particularly for asthma, wheeze, allergic rhinitis in lifetime-ever, and current wheeze. These associations and number-response relationships were more notable for visible mold spots and visible damp stains in living room and bedroom than other damp indicators, and for during pregnancy and first year of lifetime than for one year before pregnancy and in the past year before the survey. Our results provide strong evidences for the impacts of indoor dampness exposures on pediatric asthma and wheeze and seemingly suggest their potential causal relationships.
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影响因子：
15.5
作者：
Richardson, Miles;Gottel, Neil;Hampton-Marcell, Jarrad T.
通讯作者：
Hampton-Marcell, Jarrad T.
影响因子：
7.4
作者：
Yuexia Sun;Jing Hou;Xiangrui Kong;Qingnan Zhang;Pan Wang;Louise B. Weschler;J. Sundell
通讯作者：
Yuexia Sun;Jing Hou;Xiangrui Kong;Qingnan Zhang;Pan Wang;Louise B. Weschler;J. Sundell
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作者：
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通讯作者：
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影响因子：
5.8
作者：
Fisk, William J.;Chan, Wanyu R.;Johnson, Alexandra L.
通讯作者：
Johnson, Alexandra L.
影响因子：
4.4
作者：
K. Tham;M. Zuraimi;D. Koh;F. Chew;P. Ooi
通讯作者：
K. Tham;M. Zuraimi;D. Koh;F. Chew;P. Ooi