Control of behavioral flexibility by the lateral habenula.
Control of behavioral flexibility by the lateral habenula.
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DOI：
10.1016/j.pbb.2017.07.012
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发表时间：
2017-11
期刊：
影响因子：
--
通讯作者：
Mizumori SJY
中科院分区：
文献类型：
--
作者：
Baker PM;Mizumori SJY
在动态环境中快速切换行为的能力是跨物种生存的基础。认识到何时应该用替代策略取代正在进行的行为策略，需要整合生物体内部和外部的多种线索，包括饥饿、压力或奖励预测线索的存在。日益复杂的行为范式与最先进的电生理学和药理学方法相结合，描绘了与行为灵活性有关的大脑回路。然而，如何整合不同的背景线索来影响逐次试验的策略选择仍然很大程度上未知。外侧缰核 (LHb) 是整合内部和外部线索以确定持续行为策略是否合适的一个有希望的候选者。 LHb 接收来自许多大脑区域的输入，这些区域发出内部和外部环境背景的信号，然后投射到涉及行为监控和可塑性的区域。这篇综述探讨了这些联系如何与最近的药理学和电生理学结果相结合，揭示 LHb 在动态环境中行为灵活性中的关键作用。这一拟议的作用扩展了 LHb 对动机行为的已知贡献，并表明 LHb 在这些行为中的基本作用超出了向多巴胺能系统发出奖励和惩罚信号的范围。
The ability to rapidly switch behaviors in dynamic environments is fundamental to survival across species. Recognizing when an ongoing behavioral strategy should be replaced by an alternative one requires the integration of a diverse number of cues both internal and external to the organism including hunger, stress, or the presence of reward predictive cues. Increasingly sophisticated behavioral paradigms coupled with state of the art electrophysiological and pharmacological approaches have delineated a brain circuit involved in behavioral flexibility. However, how diverse contextual cues are integrated to influence strategy selection on a trial by trial basis remains largely unknown. One promising candidate for integration of internal and external cues to determine whether an ongoing behavioral strategy is appropriate is the lateral habenula (LHb). The LHb receives input from many brain areas that signal both internal and external environmental contexts and in turn projects to areas involved in behavioral monitoring and plasticity. This review examines how these connections, combined with recent pharmacological and electrophysiological results reveal a critical role for the LHb in behavioral flexibility in dynamic environments. This proposed role extends the known contributions of the LHb to motivated behaviors and suggests that the fundamental role of the LHb in these behaviors goes beyond signaling rewards and punishments to dopaminergic systems.
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DOI：
10.1080/15374416.2015.1041592
发表时间：
2016
期刊：
Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53
影响因子：
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作者：
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期刊：
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影响因子：
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DOI：
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发表时间：
1996-10-29
期刊：
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影响因子：
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GoldmanRakic, PS