Association analysis of APO gene polymorphisms with ischemic stroke risk: a case-control study in a Chinese Han population.
Association analysis of APO gene polymorphisms with ischemic stroke risk: a case-control study in a Chinese Han population.
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APO基因多态性与缺血性脑卒中风险的关联分析：中国汉族人群的病例对照研究
DOI：
10.18632/oncotarget.15549
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发表时间：
2017-09-01
期刊：
影响因子：
--
通讯作者：
Xia Y
中科院分区：
文献类型：
--
作者：
Xiao R;Sun S;Zhang J;Ouyang Y;Zhang N;Yang M;Jin T;Xia Y
本研究旨在评估载脂蛋白O基因多态性与中国汉族人群缺血性脑卒中风险的关系。本研究采用Sequenom Mass-ARRAY技术对488例脑梗死患者和503例对照者的3个载脂蛋白O基因的14个单核苷酸多态性（single nucleotide polymorphisms，SNPs）进行基因分型，并采用χ2检验和遗传模型分析评价其与缺血性脑卒中的相关性。在等位基因模型分析中，我们确定了三个SNP与缺血性卒中显著相关：rs693，p值为0.042，（OR = 1.406; 95%CI = 1.011-1.956），rs651821，p值为0.007（OR = 0.760; 95%CI = 0.622-0.929）和rs662799，p值为0.006（OR = 0.755; 95%CI = 0.618-0.923）。在遗传模型分析中，我们发现rs693的次要等位基因“A”在加性模型和显性模型中与缺血性卒中风险增加相关。在相加模型中，rs651821的次要等位基因“C”与缺血性卒中风险降低相关。在相加模型中，rs662799的次要等位基因“G”与缺血性卒中风险降低相关。此外，在APOB的rs 1042034、rs676210、rs693、rs673548、APOB的rs3791981、rs679899和APOA 5的rs651821、rs662799、rs 17120035组成的3个区域中发现了强连锁。我们的数据表明载脂蛋白O基因多态性可能影响中国汉族人群缺血性脑卒中的易感性。
This study aimed to assess the association of APO gene polymorphisms and ischemic stroke risk in a Chinese Han population. In this case-control study, we genotyped 14 single nucleotide polymorphisms (SNPs) in 3 APO genes in 488 cases and 503 controls using Sequenom Mass-ARRAY technology and evaluated their association with ischemic stroke using the χ2 and genetic model analysis. In the allelic model analysis, we determined three SNPs were significantly associated with ischemic stroke: rs693 with a p value of 0.042 (OR = 1.406; 95%CI = 1.011-1.956), rs651821 with a p value of 0.007 (OR = 0.760; 95%CI = 0.622-0.929) and rs662799 with a p value of 0.006 (OR = 0.755; 95%CI = 0.618-0.923). In the genetic model analysis, we found the minor allele “A” of rs693 was associated with an increased ischemic stroke risk in the additive model and dominant model. The minor allele “C” of rs651821 was associated with a decreased ischemic stroke risk in the additive model. The minor allele “G” of rs662799 was associated with a decreased ischemic stroke risk in the additive model. Additionally, strong linkage was found in 3 blocks constituted by rs1042034, rs676210, rs693, rs673548 in APOB; rs3791981, rs679899 in APOB; and rs651821, rs662799, rs17120035 in APOA5. Our data suggested that gene polymorphisms in the APO genes may exert influences ischemic stroke susceptibility in a Chinese Han population.
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影响因子：
--
作者：
Ruixing Y;Guangqin C;Yong W;Weixiong L;Dezhai Y;Shangling P
通讯作者：
Shangling P
影响因子：
0.5
作者：
Kallel, A.;Jemaa, R.;Kaabachi, N.
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Kaabachi, N.
影响因子：
3.3
作者：
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通讯作者：
Melegh, Bela
影响因子：
2.1
作者：
Wang, Gan-nan;Zhang, Jin-song;Xiao, Hang
通讯作者：
Xiao, Hang
影响因子：
30.8
作者：
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通讯作者：
Garraway, Levi A.