Long Term Memory Outcome of Repetitive, Low-Level Dietary Exposure to Domoic Acid in Native Americans.
Long Term Memory Outcome of Repetitive, Low-Level Dietary Exposure to Domoic Acid in Native Americans.
复制标题
美洲原住民重复，低水平饮食中的多饮食饮食的长期记忆结果。
DOI：
10.3390/ijerph18083955
复制
发表时间：
2021-04-09
影响因子：
--
通讯作者：
Morris JG
中科院分区：
文献类型：
--
作者：
Grattan LM;Kaddis L;Tracy JK;Morris JG
软骨藻酸（DA）是一种海洋神经毒素，如果通过受污染的贝类摄入，则与贝类中毒（ASP）有关。人类DA暴露水平升高的这些急性效应已得到充分描述。相比之下，较低水平的长期影响，重复的，大概安全剂量的DA（小于20 ppm）是最低限度的已知。由于居住在美国西北太平洋沿岸社区的美洲原住民（NA）特别容易受到DA暴露的影响，本研究重点关注与他们重复食用神经毒素相关的长期8年记忆结果。在8年的时间里，对500名随机选择的18-64岁的成年NA男性和女性进行了剃须刀蛤消费量、记忆力、文书速度和准确性以及抑郁症的测量。使用GEE分析对数据进行分析，同时考虑到研究年份、人口统计学因素和检查饮食暴露与结果之间关联的仪器。研究结果表明，在其他稳定的文书速度和准确性和抑郁评分的背景下，总回忆记忆显着但较小的下降。有理由相信，连续的记忆困难可能与DA暴露有关，而不是单一的ASP综合征。
Domoic acid (DA) is a marine-based neurotoxin that, if ingested via tainted shellfish, is associated with Amnesic Shellfish Poisoning (ASP). These acute effects of elevated DA exposure in humans have been well described. In contrast, the long-term impacts of lower level, repetitive, presumably safe doses of DA (less than 20 ppm) are minimally known. Since Native Americans (NA) residing in coastal communities of the Pacific NW United States are particularly vulnerable to DA exposure, this study focuses on the long-term, 8-year memory outcome associated with their repeated dietary consumption of the neurotoxin. Measures of razor clam consumption, memory, clerical speed and accuracy, and depression were administered over eight years to 500 randomly selected adult NA men and women ages 18–64. Data were analyzed using GEE analyses taking into consideration the year of study, demographic factors, and instrumentation in examining the association between dietary exposure and outcomes. Findings indicated a significant but small decline in total recall memory within the context of otherwise stable clerical speed and accuracy and depression scores. There is reason to believe that a continuum of memory difficulties may be associated with DA exposure, rather than a unitary ASP syndrome.
登录
查看更多内容
有害的藻华和公共卫生。
影响因子：
6.6
作者：
Grattan LM;Holobaugh S;Morris JG Jr
通讯作者：
Morris JG Jr
影响因子：
--
作者：
Fialkowski, Marie K.;McCrory, Megan A.;Boushey, Carol J.
通讯作者：
Boushey, Carol J.
影响因子：
4.2
作者：
Lefebvre, Kathi A.;Yakes, Betsy Jean;Grattan, Lynn
通讯作者：
Grattan, Lynn
影响因子：
56.9
作者：
Cook, Peter F.;Reichmuth, Colleen;Ranganath, Charan
通讯作者：
Ranganath, Charan
影响因子：
6.6
作者：
Besiktepe, Sengul;Ryabushko, Larisa;Lee, Raisa
通讯作者：
Lee, Raisa