Plant-Based Dietary Patterns and Breast Cancer Recurrence and Survival in the Pathways Study.
Plant-Based Dietary Patterns and Breast Cancer Recurrence and Survival in the Pathways Study.
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DOI：
10.3390/nu13103374
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发表时间：
2021-09-25
期刊：
影响因子：
5.9
通讯作者：
Cespedes Feliciano EM
中科院分区：
文献类型：
--
作者：
Anyene IC;Ergas IJ;Kwan ML;Roh JM;Ambrosone CB;Kushi LH;Cespedes Feliciano EM
植物性饮食被推荐给癌症幸存者，但它们与乳腺癌预后的关系尚未得到研究。我们评估了2005年至2013年3646名诊断为乳腺癌的女性的前瞻性队列中，长期与植物性饮食保持一致是否会降低复发和死亡的风险。参与者在诊断和6个月，25个月和72个月随访时完成了食物频率问卷，从中我们得出了植物性饮食指数，包括总体（PDI），健康（hPDI）和不健康（uPDI）。我们观察到461例复发和653例死亡，中位随访时间为9.51年。使用多变量校正的考克斯比例风险模型，我们估计了乳腺癌复发和全因、乳腺癌特异性和非乳腺癌死亡率的风险比（HR）和95%置信区间。与hPDI的一致性增加与全因风险降低相关。（HR 0.93，95% CI：0.83-1.05）和非乳腺癌死亡率（HR 0.83，95% CI：0.71-0.98），而与uPDI的一致性增加与风险增加相关（HR 1.07，95% CI：0.96-1.2和HR 1.20，95% CI：1.02-1.41）。未观察到与复发或乳腺癌特异性死亡率的相关性。总之，健康与不健康的植物性饮食模式与死亡率有不同的关联。为了提高总体生存率，乳腺癌患者的饮食建议应强调健康的植物性食物。
Plant-based diets are recommended for cancer survivors, but their relationship with breast cancer outcomes has not been examined. We evaluated whether long-term concordance with plant-based diets reduced the risk of recurrence and mortality among a prospective cohort of 3646 women diagnosed with breast cancer from 2005 to 2013. Participants completed food frequency questionnaires at diagnosis and 6-, 25-, and 72-month follow-up, from which we derived plant-based diet indices, including overall (PDI), healthful (hPDI), and unhealthful (uPDI). We observed 461 recurrences and 653 deaths over a median follow-up of 9.51 years. Using multivariable-adjusted Cox proportional hazards models, we estimated hazard ratios (HR) and 95% confidence intervals for breast cancer recurrence and all-cause, breast-cancer-specific, and non-breast-cancer mortality. Increased concordance with hPDI was associated with a reduced hazard of all-cause (HR 0.93, 95% CI: 0.83–1.05) and non-breast-cancer mortality (HR 0.83, 95% CI: 0.71–0.98), whereas increased concordance with uPDI was associated with increased hazards (HR 1.07, 95% CI: 0.96–1.2 and HR 1.20, 95% CI: 1.02–1.41, respectively). No associations with recurrence or breast-cancer-specific mortality were observed. In conclusion, healthful vs. unhealthful plant-based dietary patterns had differing associations with mortality. To enhance overall survival, dietary recommendations for breast cancer patients should emphasize healthful plant foods.
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影响因子：
4.6
作者：
Rigi S;Mousavi SM;Benisi-Kohansal S;Azadbakht L;Esmaillzadeh A
通讯作者：
Esmaillzadeh A
影响因子：
7.1
作者：
Martinez-Gonzalez, Miguel A.;Sanchez-Tainta, Ana;Estruch, Ramon
通讯作者：
Estruch, Ramon
影响因子：
4.7
作者：
Sasanfar, Bahareh;Toorang, Fatemeh;Zendehdel, Kazem
通讯作者：
Zendehdel, Kazem
DOI：
10.1080/01635581.2013.804939
发表时间：
2013
期刊：
Nutrition and cancer
影响因子：
--
作者：
Izano MA;Fung TT;Chiuve SS;Hu FB;Holmes MD
通讯作者：
Holmes MD
DOI：
10.13063/2327-9214.1049
发表时间：
2014-01-01
期刊：
EGEMS (Washington, DC)
影响因子：
--
作者：
Ross, Tyler R;Ng, Daniel;Steiner, John F
通讯作者：
Steiner, John F