Time Restricted Feeding to the Light Cycle Dissociates Canonical Circadian Clocks and Physiological Rhythms in Heart Rate.
Time Restricted Feeding to the Light Cycle Dissociates Canonical Circadian Clocks and Physiological Rhythms in Heart Rate.
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DOI：
10.3389/fphar.2022.910195
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发表时间：
2022
影响因子：
5.6
通讯作者：
Delisle, Brian P.
中科院分区：
文献类型：
--
作者：
Schroder, Elizabeth A.;Delisle, Brian P.
昼夜节律是大约24小时的生物周期，优化分子和生理功能，以预测日常环境变化，以维持内部和生物体的稳态。环境刺激（光、喂养、活动）能够改变分子节律的阶段，是昼夜节律生物学家用来增加对多细胞系统中昼夜节律与环境以及彼此之间同步的理解的重要工具。位于下丘脑视交叉上核（SCN）的中央生物钟主要对光有反应，并被认为通过神经体液信号来调控外周生物钟的相位。老鼠是夜行动物，在黑暗周期消耗大部分食物。早期的研究表明，以时间限制喂养的形式改变的代谢信号，特别是在光循环期间喂养小鼠，导致外周组织与SCN分子钟的解耦。这些研究表明，一些外周组织的基因表达在12小时内发生了变化，而其他组织则没有。这些变化发生时，大脑的中央时钟并没有相应的变化。最近的研究表明，心脏生理学（心率，MAP）对食物摄入时间的反应是独立于心脏分子钟的。了解其他器官的生理/功能和基因表达的差异，无论是独立的还是与心脏相关的，以响应改变的摄食，对于解剖全身各种时钟的作用，以及了解它们与心血管病理的联系都是重要的。
Circadian rhythms are approximate 24-h biological cycles that optimize molecular and physiological functions to predictable daily environmental changes in order to maintain internal and organismal homeostasis. Environmental stimuli (light, feeding, activity) capable of altering the phase of molecular rhythms are important tools employed by circadian biologists to increase understanding of the synchronization of circadian rhythms to the environment and to each other within multicellular systems. The central circadian clock, located in the suprachiasmatic nucleus (SCN) of the hypothalamus is largely responsive to light and is thought to entrain the phase of peripheral clocks via neurohumoral signals. Mice are nocturnal and consume most of their food during the dark cycle. Early studies demonstrated that altered metabolic cues in the form of time restricted feeding, specifically, feeding mice during the light cycle, resulted in an uncoupling of molecular clocks in peripheral tissues with those from the SCN. These studies showed as much as a 12-h shift in gene expression in some peripheral tissues but not others. The shifts occurred without corresponding changes in the central clock in the brain. More recent studies have demonstrated that changes in cardiac physiology (heart rate, MAP) in response to time of food intake occur independent of the cardiac molecular clock. Understanding differences in the physiology/function and gene expression in other organs both independently and in relation to the heart in response to altered feeding will be important in dissecting the roles of the various clocks throughout the body, as well as, understanding their links to cardiovascular pathology.
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影响因子：
25
作者：
Gooley, JJ;Lu, J;Saper, CB
通讯作者：
Saper, CB
DOI：
10.1152/ajpheart.00238.2012
发表时间：
2012-08-01
影响因子：
4.8
作者：
Lefta, Mellani;Campbell, Kenneth S.;Esser, Karyn A.
通讯作者：
Esser, Karyn A.
影响因子：
56.9
作者：
Balsalobre, A;Brown, SA;Schibler, U
通讯作者：
Schibler, U
影响因子：
13.9
作者：
Mohawk JA;Green CB;Takahashi JS
通讯作者：
Takahashi JS
影响因子：
2.1
作者：
Dampney, Roger A. L.
通讯作者：
Dampney, Roger A. L.