The effects of drugs on wound healing: part 1

The effects of drugs on wound healing: part 1
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药物对伤口愈合的影响:第 1 部分

DOI:
10.1046/j.1365-4362.2000.00948.x
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发表时间:
2000
影响因子:
3.6
通讯作者:
L. Millikan
L. Millikan
中科院分区:
医学4区
文献类型:
--
作者:
S. Karukonda;T. Flynn;E. Boh;E. McBurney;G. Russo;L. Millikan

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在讨论药物对伤口愈合的影响时,了解基本的伤口愈合生理学非常重要。过去 20 年来,伤口愈合领域取得了重大进展。在“药物对伤口愈合的影响”的第一部分中,讨论了伤口愈合的各个阶段,概述了局部因素的重要性,并介绍了药物对伤口愈合特定阶段的影响。第 2 部分详细介绍了特定类别的药物及其对伤口愈合的影响。伤口愈合涉及五个阶段。这些连续的阶段被称为:损伤、凝血、炎症、组织形成和组织重塑。每个阶段持续特定的时间长度,并具有特征性的细胞元件和细胞外因子,以及充当信号、抑制子和促进子的细胞因子和生长因子。图 1 显示了伤口愈合级联并记录了各个阶段。表 1 详细介绍了所涉及的细胞和细胞外元素。
An understanding of basic wound healing physiology is important when discussing the effects of drugs on wound healing. Major advances have occurred within the field of wound healing in the last 20 years. In Part 1 of “The effects of drugs on wound healing”, the phases of wound healing are discussed, the importance of local factors are outlined, and the effects of pharmacologic agents on specific phases of wound healing are presented. Part 2 details specific classes of drugs and their impact on the healing wound. Wound healing involves five phases. These sequential phases are termed: injury, coagulation, inflammation, tissue formation, and tissue remodeling. Each phase lasts a specific length of time and has characteristic cellular elements and extracellular agents, as well as cytokines and growth factors which act as signals, suppressors, and promoters. Figure 1 shows the wound healing cascade and documents the phases. Table 1 details the cellular and extracellular elements involved.
DOI: 10.1056/nejm198411293112205
发表时间: 1984-11
期刊: The New England journal of medicine
影响因子: --
作者:
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