The half-life of maternal transplacental antibodies against diphtheria, tetanus, and pertussis in infants: an individual participant data meta-analysis.
The half-life of maternal transplacental antibodies against diphtheria, tetanus, and pertussis in infants: an individual participant data meta-analysis.
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DOI：
10.1016/j.vaccine.2021.12.007
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发表时间：
2022-01-24
期刊：
影响因子：
5.5
通讯作者：
Voysey, Merryn
中科院分区：
文献类型：
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作者：
Oguti, Blanche;Ali, Asad;Andrews, Nick;Barug, Daan;Duc Anh Dang;Halperin, Scott A.;Ha Thi Thu Hoang;Holder, Beth;Kampmann, Beate;Kazi, Abdul M.;Langley, Joanne M.;Leuridan, Elke;Madavan, Naomi;Maertens, Kirsten;Maldonado, Herberth;Miller, Elizabeth;Munoz-Rivas, Flor M.;Omer, Saad B.;Pollard, Andrew J.;Rice, Thomas F.;Rots, Nynke;Sundaram, Maria E.;Wanlapakorn, Nasamon;Voysey, Merryn
对于初级系列疫苗中发现的抗原的母体抗体的半衰期几乎没有可靠的估计。我们的目的是计算婴儿被动获得的白喉、破伤风和百日咳 (DTP) 抗体的半衰期。我们的目的是确定衰减率是否因国家、产妇年龄、胎龄、出生体重、世界银行收入分类或母亲在怀孕期间接种的疫苗而变化。来自参加 9 个国家（英国、比利时、泰国、越南、加拿大、巴基斯坦、美国、危地马拉和荷兰）的 10 项研究的女性所生婴儿的去识别化数据被合并到一项个体参与者数据荟萃分析中。在婴儿接种任何含百白破疫苗之前的两个时间点采集血样：出生时和两个月大时。对每种抗原的衰减率进行log2转换并应用混合效应模型。通过取平均衰减率绝对值的倒数来计算半衰期。分析中纳入了 1426 对母婴的数据。 6 种感兴趣的抗原特异性母体抗体的半衰期相似，点估计值范围从破伤风类毒素抗体的 28.7 (95% CI: 24.4 – 35) 天到百日咳杆菌粘附素抗体的 35.1 (95% CI: 30.7 – 41.1) 天。母体抗体的衰减并没有因母体年龄、胎龄、出生体重、母体疫苗接种状态或所注射疫苗类型的不同而显着差异。对于不同的抗原，母体抗体以不同的速率衰减；然而，差异的幅度很小。衰变率不会因关键人口或疫苗特征而改变。
There are few reliable estimates of the half-lives of maternal antibodies to the antigens found in the primary series vaccines. We aimed to calculate the half-lives of passively acquired diphtheria, tetanus and pertussis (DTP) antibodies in infants. We aimed to determine whether decay rates varied according to country, maternal age, gestational age, birthweight, World Bank income classifications, or vaccine received by the mother during pregnancy. De-identified data from infants born to women taking part in 10 studies, in 9 countries (UK, Belgium, Thailand, Vietnam, Canada, Pakistan, USA, Guatemala and the Netherlands) were combined in an individual participant data meta-analysis. Blood samples were taken at two timepoints before any DTP-containing vaccines were received by the infant: at birth and at 2-months of age. Decay rates for each antigen were log2-transformed and a mixed effects model was applied. Half-lives were calculated by taking the reciprocal of the absolute value of the mean decay rates. Data from 1426 mother-infant pairs were included in the analysis. The half-lives of the 6 antigen-specific maternal antibodies of interest were similar, with point estimates ranging from 28.7 (95% CI: 24.4 – 35) days for tetanus toxoid antibodies to 35.1 (95% CI: 30.7 – 41.1) days for pertactin antibodies. The decay of maternal antibodies did not significantly differ by maternal age, gestational age, birthweight, maternal vaccination status or type of vaccine administered. Maternal antibodies decay at different rates for the different antigens; however, the magnitude of the difference is small. Decay rates are not modified by key demographic or vaccine characteristics.
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影响因子：
--
作者：
Palmeira P;Quinello C;Silveira-Lessa AL;Zago CA;Carneiro-Sampaio M
通讯作者：
Carneiro-Sampaio M
DOI：
10.1093/cid/ciw559
发表时间：
2016-12-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Amirthalingam G;Campbell H;Ribeiro S;Fry NK;Ramsay M;Miller E;Andrews N
通讯作者：
Andrews N
影响因子：
6.1
作者：
Jauniaux, E;Jurkovic, D;Campbell, S
通讯作者：
Campbell, S
影响因子：
6.7
作者：
Langel, Stephanie N.;Otero, Claire E.;Permar, Sallie R.
通讯作者：
Permar, Sallie R.
北京市顺义地区白喉、破伤风、百日咳、麻疹、流行性腮腺炎、风疹母源及脐带特异性抗体血清阳性率分析
影响因子：
4.6
作者：
Meng, Qing-hong;Liu, Ying;Yao, Kai-hu
通讯作者：
Yao, Kai-hu