Diagnostic accuracy and practice effects in the National Alzheimer's Coordinating Center Uniform Data Set neuropsychological battery.

Diagnostic accuracy and practice effects in the National Alzheimer's Coordinating Center Uniform Data Set neuropsychological battery.
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DOI:
10.1016/j.jalz.2013.11.007
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发表时间:
2014-11
期刊:
Alzheimer's & dementia : the journal of the Alzheimer's Association
影响因子:
--
通讯作者:
Schmitt FA
Schmitt FA
中科院分区:
其他
文献类型:
--
作者:
Mathews M;Abner E;Kryscio R;Jicha G;Cooper G;Smith C;Caban-Holt A;Schmitt FA

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统一数据集(UDS)神经心理学电池经常用于临床研究。然而,实践效果、作为整体认知功能衡量标准的有效性以及轻度认知障碍的检测尚未得到检验。 UDS 的规范总分已经制定。线性判别分析确定了识别认知正常组和受损组的分类准确性。在认知正常和认知受损的群体中检查了练习效果。总分可以区分认知正常的参与者和患有痴呆症的参与者,但不能准确识别患有轻度认知障碍(MCI)的个体。在正常组和 MCI 组中,接受过测试的参与者的平均总分均显着高于未参加过测试的参与者,并且在痴呆组中也更高,但不显着。总分的分类准确性区分了认知正常的参与者和患有痴呆症的参与者。总分似乎受到练习效果的影响。
The Uniform Data Set (UDS) neuropsychological battery is frequently used in clinical studies. However, practice effects, effectiveness as a measure of global cognitive functioning, and detection of mild cognitive impairment have not been examined. A normative total score for the UDS has been developed. Linear discriminant analysis determined classification accuracy in identifying cognitively normal and impaired groups. Practice effects were examined in cognitively normal and cognitively impaired groups. The total score differentiates between cognitively normal participants and those with dementia, but does not accurately identify individuals with mild cognitive impairment (MCI). Mean total scores for test-exposed participants were significantly higher than test-naive participants in both the normal and MCI groups and were higher, but not significantly so, in the dementia group. The total score’s classification accuracy discriminates between cognitively normal versus participants who have dementia. The total score appears subject to practice effects.
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