Acute rewarding and disinhibiting effects of alcohol as indicators of drinking habits.
Acute rewarding and disinhibiting effects of alcohol as indicators of drinking habits.
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DOI：
10.1007/s00213-020-05667-w
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发表时间：
2021-01
影响因子：
3.4
通讯作者：
Fillmore MT
中科院分区：
文献类型：
--
作者：
Allen HC;Weafer J;Wesley MJ;Fillmore MT
实验室研究已经可靠地表明，对酒精奖励效果的高度敏感性与酗酒模式有关。最近，有研究表明，对酒精去抑制作用的高度敏感性也可能导致饮酒习惯。大多数关于酒精急性效应的研究都集中在参与者的平均饮酒量上，很少关注个体差异如何影响酒精滥用的可能性。在很大程度上，这是由于以前实验室研究的样本量有限。本研究克服了以往的局限性，在大样本中测试了对酒精的奖励和去抑制作用的急性敏感性和耐受性的个体差异与饮酒行为的关系程度。汇总了来自六项实验室研究的数据，包括181名成年人的样本。参与者的“喜欢”水平（酒精的影响）和去抑制水平在血液酒精浓度（BAC）曲线上升段分别以0.65 g/kg酒精进行评估，在曲线下降段以相同的BAC进行评估。在服用安慰剂后也对这些措施进行了评估。酒精增加了喜欢和行为抑制的评级。大量饮酒与对上升肢体的喜好的高度敏感性有关。此外，那些对去抑制和喜欢都表现出较低的急性耐受性的人也是重度饮酒者。这些数据表明，喜欢酒精影响的个体差异和持续的去抑制是饮酒习惯的关键指标。
Laboratory studies have reliably shown that heightened sensitivity to the rewarding effects of alcohol is associated with heavier drinking patterns. More recently, there has been research to suggest that heightened sensitivity to the disinhibiting effects of alcohol might also contribute to drinking habits. Most research on the acute effects of alcohol has focused on drinking magnitudes averaged across participants with little attention paid to how individual differences influence alcohol abuse potential. In large part, this is due to limited sample sizes in previous laboratory studies. This study overcomes previous limitations by testing the degree to which individual differences in acute sensitivity and tolerance to the rewarding and disinhibiting effects of alcohol relate to drinking behavior in a large sample size. Data from six laboratory studies were aggregated to comprise a sample of 181 adults. Participants’ level of “liking” (the effects of alcohol) and disinhibition were assessed following 0.65 g/kg alcohol once during the ascending limb of the blood alcohol concentration (BAC) curve and again at the same BAC during the descending limb of the curve. The measures were also assessed following placebo. Alcohol increased ratings of liking and behavioral disinhibition. Heavier drinking was associated with heightened sensitivity to liking on the ascending limb. Additionally, those who showed reduced acute tolerance to both disinhibition and liking were also heavier drinkers. These data suggest that individual variability in liking the effects of alcohol and persistent disinhibition are key indicators of drinking habits.
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影响因子：
3.4
作者：
Clay JM;Parker MO
通讯作者：
Parker MO
DOI：
10.1111/j.1530-0277.2007.00378.x
发表时间：
2007-06-01
影响因子：
3.2
作者：
Goudriaan, Anna E.;Grekin, Emily R.;Sher, Kenneth J.
通讯作者：
Sher, Kenneth J.
影响因子：
5.3
作者：
Gilman, Jodi M.;Ramchandani, Vijay A.;Hommer, Daniel W.
通讯作者：
Hommer, Daniel W.
影响因子：
6
作者：
Fillmore, MT;Weafer, J
通讯作者：
Weafer, J
影响因子：
3.4
作者：
Fillmore, Mark T.;Weafer, Jessica
通讯作者：
Weafer, Jessica